CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM551
Family Name Cathepsin S inhibitor ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(1-methylcyclopropanecarbonyl)amino]propanoyl]amino]-2-oxo-4-phenylmethoxybutanoyl]amino]acetate family
No. of Seeds 3 No. of Other Members 8
Family Centroid CFAMM00313152 Functional Category Bioactive with Natural Product
Superfamily Cathepsin S and Proteasome subunit beta type-2 Binder Superfamily
Class Class 610

Cousin Family NamesSeedsMembers
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Sodium channel protein type 5 subunit alpha Ligand Hexylcaine ... 4 94
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
VTP-27999 family 24 23
Ezatiostat family 1 4
Flovagatran family 12 546
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Cruzipain Inhibitor WRR-204 Family 18 35
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-lle-agly-ile-v... 17 7
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-nal-agly-ile-v... 3 2
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Cathepsin B and Cathepsin S Inhibitor Cbz-ile-leu-ala-leuvsme ... 12 14
Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Family 13 18
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Gamma-secretase subunit APH-1B and Presenilin-1 Inhibitor 3114... 8 9
Pol polyprotein inhibitor benzyl N-[(2S,3R)-1-[[(2S,3R,4R)-4-(... 5 26
Cathepsin K inhibitor (4-phenylphenyl) (3S)-3-[[(3S)-1,2-dioxo... 4 10
Cathepsin S inhibitor ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(2-th... 2 5
Cathepsin S inhibitor SureCN6857538 family 2 12
Cathepsin S inhibitor ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(4-me... 2 9
Pol polyprotein inhibitor benzyl N-[(2S)-1-[[(2S,3S,4R,5S)-3,4... 21 5
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 2 2
Neprilysin and Aminopeptidase N inhibitor benzyl 2-[[(2S)-2-[[... 1 1
Angiotensin-converting enzyme inhibitor (2R)-1-[4-carboxy-4-(p... 3 3
Growth hormone secretagogue receptor type 1 ligand SureCN63170... 1 1
Caspase-1 inhibitor (3S)-5-(3,3-diphenylpropanoyloxy)-3-[[(2S)... 3 6
Caspase-1 inhibitor (3S)-5-[[(3aS,7aS)-2-oxo-3a,4,5,6,7,7a-hex... 3 0
Peptidyl-prolyl cis-trans isomerase FKBP1A and Peptidyl-prolyl... 4 27
Cathepsin B and Calpain-2 catalytic subunit inhibitor AGN-PC-0... 2 2
Cathepsin B and Calpain-1 catalytic subunit inhibitor AGN-PC-0... 3 1
Cathepsin B and Cathepsin L1 inhibitor 3-[[(2R)-2-cyano-2-[[(2... 3 4
Cathepsin S inhibitor SureCN7397817 family 9 4
Pol polyprotein inhibitor benzyl N-[(2S,3R)-4-[(3aR,6S,7aS)-6-... 3 2
Neutrophil elastase inhibitor benzyl N-[(2S)-1-[(2S)-2-[[(3S)-... 4 0
Neutrophil elastase inhibitor benzyl N-[(2S)-3-methyl-1-[(2S)-... 2 0
Pol polyprotein inhibitor AC1LADQG family 7 1
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 4 7
Pol polyprotein inhibitor benzyl N-[(2S)-4-amino-1-[[(2S,3R)-4... 2 1
Cathepsin S inhibitor (2R)-N-[(1R)-2-[(4-chlorophenyl)methoxy]... 2 0
Proteasome subunit beta type-5 and Proteasome subunit beta typ... 1 0
Neutrophil elastase inhibitor 1-O-benzyl 4-O-ethyl (3aS,6R,6aR... 3 4
Renin inhibitor AGN-PC-076HPD family 1 0
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 1 0
Neprilysin inhibitor benzyl (2S)-2-[[2-(sulfanylmethyl)-3,4-di... 4 0
Protease inhibitor AC1O54RX family 2 4
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3R)-1-cyclohexyl-3-h... 2 0
Neutrophil collagenase and Matrix metalloproteinase-9 inhibito... 1 0
Pol polyprotein inhibitor benzyl N-[(2R)-1-[[(1S)-1-[(2R,3S)-3... 3 1
C-C chemokine receptor type 5 ligand benzyl N-[1-[(4S)-4-(cycl... 1 0
Calpain-1 catalytic subunit and Cathepsin B inhibitor (2R)-N-[... 2 2
Gamma-secretase subunit PEN-2 inhibitor SureCN5966881 family 1 9
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 1-... 1 0
Angiotensin-converting enzyme and Angiotensin-converting enzym... 1 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2S,4R)... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00313148 CHEMBL1083318 Bioactive ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-(morpholine-4-carbonylamino)propanoyl]amino]-2-oxo-4-phenylmethoxybutanoyl]amino]acetate
CFAMM00313153 CHEMBL1085966 Bioactive ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(2,2-dimethyl-4-oxo-3H-pyran-6-carbonyl)amino]propanoyl]amino]-2-oxo-4-phenylmethoxybutanoyl]amino]acetate
CFAMM00313152 CHEMBL1083930 Bioactive ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(1-methylcyclopropanecarbonyl)amino]propanoyl]amino]-2-oxo-4-phenylmethoxybutanoyl]amino]acetate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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