CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM554
Family Name Prostaglandin E2 receptor EP4 subtype and Prostaglandin D2 receptor ligand 4-[(1S)-1-[[5-chloro-1-[[4-(trifluoromethyl)phenyl]methyl]indole-7-carbonyl]amino]ethyl]benzoic acid family
No. of Seeds 8 No. of Other Members 17
Family Centroid CFAMM00313187 Functional Category Bioactive with Natural Product
Superfamily Prostaglandin D2 receptor and Prostaglandin E2 receptor EP4 subtype Binder Superfamily
Class Class 3182

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Dolasetron Family 12 171
Dihydroorotate dehydrogenase Inhibitor Brequinar Family 9 122
Retinoic acid receptor alpha Ligand LG100268 Family 2 33
Coagulation factor X Inhibitor Otamixaban Family 9 21
Dihydroorotate dehydrogenase Inhibitor Cinchoninic Acid Family 1 21
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Prostaglandin E synthase Inhibitor L-655240 Family 3 46
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Lethal factor Inhibitor 3-(2,5-dimethyl-1h-pyrrol-1-yl)benzoic... 2 44
Fatty acid-binding protein, adipocyte Inhibitor 1-benzyl-2,3-d... 1 8
Cytosolic phospholipase A2 Inhibitor WAY-196025 Family 4 13
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Coagulation factor X inhibitor (2S)-(3'-AMIDINO-3-BIPHENYL)-5-... 1 0
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 2 22
Prostaglandin E2 receptor EP4 subtype and Prostaglandin D2 rec... 1 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 3 28
NS5B protein inhibitor AC1NQMYG family 6 12
Renin inhibitor [(2S,4S,5S,7R)-4-amino-8-(butylamino)-5-hydrox... 3 1
Retinoic acid receptor alpha and Retinoic acid receptor beta l... 1 2
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 4
Prostaglandin E2 receptor EP4 subtype ligand SureCN3567929 family 10 3
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4S,... 5 2
NS5B protein inhibitor AC1NQMYP family 5 0
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 10 2
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 7 0
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 2 1
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 2 0
Hydroxycarboxylic acid receptor 2 and Cytochrome P450 2C9 liga... 2 6
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
Rho-associated protein kinase 2 inhibitor 2-hydroxyethyl 3-[2-... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 1 3
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Gonadotropin-releasing hormone receptor ligand 4-[2-[[(2S)-2-[... 1 0
Beta-3 adrenergic receptor ligand SureCN5704018 family 4 1
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 5
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 2
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 4 4
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 1 1
Glutamate carboxypeptidase 2 inhibitor 1-[(3-carboxyphenyl)met... 4 11
ATP-sensitive inward rectifier potassium channel 11 ligand N-[... 1 1
Bromodomain-containing protein 3 and Bromodomain-containing pr... 2 0
Phenylpiperazines Metabolite Antrafenine Family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00313182 CHEMBL1085081 Bioactive SureCN1748992
CFAMM00313188 CHEMBL1085041 Bioactive 4-[(1S)-1-[[1-[(3-chlorophenyl)methyl]-5-fluoroindole-7-carbonyl]amino]ethyl]benzoic acid
CFAMM00313174 CHEMBL1085040 Bioactive SureCN1748860
CFAMM00313187 CHEMBL1083400 Bioactive 4-[(1S)-1-[[5-chloro-1-[[4-(trifluoromethyl)phenyl]methyl]indole-7-carbonyl]amino]ethyl]benzoic acid
CFAMM00313173 CHEMBL1084009 Bioactive AGN-PC-04VKRY
CFAMM00313179 CHEMBL1086490 Bioactive AGN-PC-04VK9U
CFAMM00313185 CHEMBL1084553 Bioactive 4-[(1S)-1-[[1-[[4-(trifluoromethyl)phenyl]methyl]indole-7-carbonyl]amino]ethyl]benzoic acid
CFAMM00313184 CHEMBL1084551 Bioactive SureCN1749071

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24631 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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