CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5551
Family Name Substance-K receptor ligand (5S)-1-(2-cyclopropylethyl)-5-(3,4-dichlorophenyl)-5-[2-[3-(4-fluoropiperidin-1-yl)azetidin-1-yl]ethyl]piperidin-2-one family
No. of Seeds 10 No. of Other Members 0
Family Centroid CFAMM00364663 Functional Category Bioactive
Superfamily Neuromedin-K receptor Ligand Osanetant Superfamily
Class Class 908

Cousin Family NamesSeedsMembers
Neuromedin-K receptor Ligand Osanetant Family 38 192
Tumor necrosis factor Inhibitor Talactoferrin Alfa Family 26 131
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 10 52
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Substance-P receptor ligand 4-[1-[2-[1-(cyclopropylmethyl)-3-(... 10 6
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 9 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 5 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 3 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 2 0
Substance-P receptor ligand 1-(cyclohexylmethyl)-5-(3,4-dichlo... 8 1
Sigma non-opioid intracellular receptor 1 ligand 1-[2-(3,4-dic... 8 4
Neuromedin-K receptor ligand (1S,2R)-1-(3,4-dichlorophenyl)-N-... 8 0
Substance-K receptor ligand SureCN3083325 family 4 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 1 1
Sodium-dependent serotonin transporter and Transporter inhibit... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00364666 CHEMBL355973 Bioactive 4-[1-[2-[1-(cyclopropylmethyl)-3-(3,4-dichlorophenyl)-6-oxopiperidin-3-yl]ethyl]azetidin-3-yl]piperazine-1-carboxamide
CFAMM00364661 CHEMBL345309 Bioactive 5-[2-[3-(4-aminopiperidin-1-yl)azetidin-1-yl]ethyl]-1-(cyclopropylmethyl)-5-(3,4-dichlorophenyl)piperidin-2-one
CFAMM00364660 CHEMBL150842 Bioactive 1-(cyclopropylmethyl)-5-(3,4-dichlorophenyl)-5-[2-[3-(4-oxopiperidin-1-yl)azetidin-1-yl]ethyl]piperidin-2-one
CFAMM00364659 CHEMBL151289 Bioactive 1-(cyclopropylmethyl)-5-(3,4-dichlorophenyl)-5-[2-[3-(4-hydroxypiperidin-1-yl)azetidin-1-yl]ethyl]piperidin-2-one
CFAMM00364665 CHEMBL180049 Bioactive (5S)-1-(cyclopropylmethyl)-5-(3,4-dichlorophenyl)-5-[2-[3-(4-ethoxypiperidin-1-yl)azetidin-1-yl]ethyl]piperidin-2-one
CFAMM00364658 CHEMBL151288 Bioactive 1-(cyclopropylmethyl)-5-(3,4-dichlorophenyl)-5-[2-[3-(4-ethoxypiperidin-1-yl)azetidin-1-yl]ethyl]piperidin-2-one
CFAMM00364664 CHEMBL359903 Bioactive (5S)-1-(cyclopropylmethyl)-5-(3,4-dichlorophenyl)-5-[2-[3-(4-fluoropiperidin-1-yl)azetidin-1-yl]ethyl]piperidin-2-one
CFAMM00364657 CHEMBL367348 Bioactive (5S)-5-[2-[3-(4-aminopiperidin-1-yl)azetidin-1-yl]ethyl]-1-(cyclopropylmethyl)-5-(3,4-dichlorophenyl)piperidin-2-one
CFAMM00364663 CHEMBL185133 Bioactive (5S)-1-(2-cyclopropylethyl)-5-(3,4-dichlorophenyl)-5-[2-[3-(4-fluoropiperidin-1-yl)azetidin-1-yl]ethyl]piperidin-2-one
CFAMM00364662 CHEMBL149794 Bioactive 1-[1-[2-[1-(cyclopropylmethyl)-3-(3,4-dichlorophenyl)-6-oxopiperidin-3-yl]ethyl]azetidin-3-yl]piperidine-4-carboxylic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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