CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5609
Family Name Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-[2-[3-(4-hydroxypiperidin-1-yl)azetidin-1-yl]ethyl]piperidin-2-one family
No. of Seeds 5 No. of Other Members 0
Family Centroid CFAMM00364873 Functional Category Bioactive
Superfamily Neuromedin-K receptor Ligand Osanetant Superfamily
Class Class 908

Cousin Family NamesSeedsMembers
Neuromedin-K receptor Ligand Osanetant Family 38 192
Kappa-type opioid receptor Ligand Asimadoline Family 14 54
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
Tumor necrosis factor Inhibitor Talactoferrin Alfa Family 26 131
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Substance-P receptor ligand 4-[1-[2-[1-(cyclopropylmethyl)-3-(... 10 6
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 9 0
Substance-K receptor ligand (5S)-1-(2-cyclopropylethyl)-5-(3,4... 10 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 3 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 2 0
Substance-P receptor ligand 1-(cyclohexylmethyl)-5-(3,4-dichlo... 8 1
Neuromedin-K receptor ligand (1S,2R)-1-(3,4-dichlorophenyl)-N-... 8 0
Prostaglandin D2 receptor 2 ligand SureCN4942606 family 2 8
Kappa-type opioid receptor ligand 3,4-dichloro-N-[2-[[(1S)-2-[... 1 0
Substance-K receptor ligand SureCN3083325 family 4 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 1 1
Neuromedin-K receptor and Substance-K receptor ligand AGN-PC-0... 2 0


External ID

Functional Category

Molecule Name

CFAMM00364873 CHEMBL151177 Bioactive 1-benzyl-5-(3,4-dichlorophenyl)-5-[2-[3-(4-hydroxypiperidin-1-yl)azetidin-1-yl]ethyl]piperidin-2-one
CFAMM00364872 CHEMBL150381 Bioactive 1-benzyl-5-(3,4-dichlorophenyl)-5-[2-[3-[2-hydroxyethyl(methyl)amino]azetidin-1-yl]ethyl]piperidin-2-one
CFAMM00364871 CHEMBL151231 Bioactive 1-benzyl-5-(3,4-dichlorophenyl)-5-[2-[3-(3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl)azetidin-1-yl]ethyl]piperidin-2-one
CFAMM00364870 CHEMBL150537 Bioactive 1-benzyl-5-(3,4-dichlorophenyl)-5-[2-[3-(3-hydroxypyrrolidin-1-yl)azetidin-1-yl]ethyl]piperidin-2-one
CFAMM00364869 CHEMBL150585 Bioactive 1-benzyl-5-(3,4-dichlorophenyl)-5-[2-[3-(3-hydroxypiperidin-1-yl)azetidin-1-yl]ethyl]piperidin-2-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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