CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5610
Family Name Metabotropic glutamate receptor 1 and Metabotropic glutamate receptor 5 ligand AGN-PC-077R1S family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00364876 Functional Category Bioactive
Superfamily Metabotropic glutamate receptor 5 and Metabotropic glutamate receptor 1 Binder Superfamily
Class Class 4291

Cousin Family NamesSeedsMembers
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Transient receptor potential cation channel subfamily V member... 6 66
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
GDC-0349 family 44 77
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Farnesyl pyrophosphate synthase Inhibitor Minodronate Family 1 0
Glucan synthesis regulatory protein Inhibitor Pyridobenzimidaz... 2 12
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Survival motor neuron protein and Menin inhibitor CHEMBL132797... 1 1
Sorbitol dehydrogenase inhibitor SureCN6335187 family 2 6
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 1
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Adenosine deaminase inhibitor AGN-PC-00FYYU family 4 5
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
D(4) dopamine receptor and Alpha-1D adrenergic receptor ligand... 3 3
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 0
CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... 1 4
Delta-type opioid receptor and Kappa-type opioid receptor liga... 10 4
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 1 2
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Cathepsin K inhibitor SureCN4141224 family 3 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family 3 1
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00364876 CHEMBL452618 Bioactive AGN-PC-077R1S
CFAMM00364879 CHEMBL456823 Bioactive AGN-PC-077R1T

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27058 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543