CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM562
Family Name Protein kinase C theta type and Protein kinase C delta type inhibitor 5-[(E)-2-[5-[[4-(2-hydroxyethyl)piperazin-1-yl]methyl]pyridin-2-yl]ethenyl]-4-[(4-methyl-1H-indol-5-yl)amino]pyridine-3-carbonitrile family
No. of Seeds 16 No. of Other Members 8
Family Centroid CFAMM00170617 Functional Category Bioactive with Natural Product
Superfamily Protein kinase C theta type and Protein kinase C delta type Binder Superfamily
Class Class 1666

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Transient receptor potential cation channel subfamily V member... 15 457
Glucagon receptor Ligand Dwlip-gcgrrx Family 5 26
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
E7820 family 9 56
JAK Inhibitor Momelotinib Family 33 83
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... 4 19
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Protein kinase C theta type and Protein kinase C delta type in... 7 17
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Acetylcholinesterase and Cholinesterase inhibitor 3,8-DIAMINO-... 2 3
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Glucocorticoid receptor ligand SureCN5650626 family 17 25
Mitogen-activated protein kinase 10 and Transcription factor A... 4 4
Glucocorticoid receptor and Androgen receptor ligand AGN-PC-0A... 3 0
Hepatocyte growth factor receptor ligand AGN-PC-08XYH0 family 8 4
Hepatocyte growth factor receptor ligand AGN-PC-08XYH3 family 1 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 12 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
CGMP-dependent protein kinase inhibitor AGN-PC-075XJ0 family 9 1
Transient receptor potential cation channel subfamily V member... 4 0
Transporter and Sodium-dependent serotonin transporter inhibit... 2 1
Serine/threonine-protein kinase ATR and Serine/threonine-prote... 8 10
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 4
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Serine/threonine-protein kinase Chk1 inhibitor 5-[7-(2-morphol... 2 2
CGMP-dependent protein kinase inhibitor methyl 2-[[4-[5-(4-flu... 6 1
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Epidermal growth factor receptor ligand Pyrroloquinazoline der... 7 0
Epidermal growth factor receptor and Vascular endothelial grow... 14 19
Protein kinase C theta type and Protein kinase C delta type in... 4 5
G2/mitotic-specific cyclin-B2 and Cyclin-dependent kinase 1 in... 2 1
Protein kinase C theta type and Tyrosine-protein kinase Fyn in... 4 0
CGMP-dependent protein kinase inhibitor AGN-PC-078XQ0 family 1 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 1
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN413... 1 1
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00313256 CHEMBL595724 Bioactive 5-[(E)-4-[(3R)-3-hydroxypyrrolidin-1-yl]but-1-enyl]-4-[(4-methyl-1H-indol-5-yl)amino]pyridine-3-carbonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26233 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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