CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5623
Family Name Thromboxane-A synthase and Thromboxane A2 receptor ligand SureCN8055988 family
No. of Seeds 5 No. of Other Members 37
Family Centroid CFAMM00365000 Functional Category Bioactive
Superfamily Beta-3 adrenergic receptor and Pol polyprotein Binder Superfamily
Class Class 630

Cousin Family NamesSeedsMembers
Cyclooxygenase Inhibitor Oxaprozin Family 33 450
Pristinamycin family 2 2
Phospholipase A2, membrane associated Inhibitor Varespladib Fa... 37 190
C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... 3 52
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Fatty-acid amide hydrolase 1 Inhibitor 1-(5-(pyridin-2-yl)oxaz... 10 142
Prostacyclin receptor and Prostaglandin E2 receptor EP3 subtyp... 4 17
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-[5-(4-hydroxyphe... 4 36
Peroxisome proliferator-activated receptor alpha Ligand BMS-68... 10 16
Renin Inhibitor CP-305202 Family 9 30
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 1 4
Peroxisome proliferator-activated receptor delta ligand SureCN... 8 19
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[3-(1,3-be... 3 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 5 25
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 21
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Pol polyprotein inhibitor AC1LARNY family 28 17
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 13 0
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Retinoic acid receptor beta and Retinoic acid receptor alpha l... 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 3
Thyroid hormone receptor beta ligand CHEMBL1397256 family 1 12
B2 bradykinin receptor ligand SureCN6640854 family 7 4
Inosine-5'-monophosphate dehydrogenase inhibitor SureCN1318237... 2 12
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 0
Fatty-acid amide hydrolase 1 inhibitor methyl 6-[2-[3-(4-pheny... 8 5
Fatty-acid amide hydrolase 1 inhibitor [(2S)-6-phenoxy-1,2,3,4... 3 6
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 4 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 1
Sphingosine 1-phosphate receptor 1 ligand 6-[2-[6-propan-2-ylo... 1 1
Sphingosine 1-phosphate receptor 1 ligand 6-[2-[4-phenyl-3-(tr... 2 3
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 14 24
Sphingosine 1-phosphate receptor 1 ligand AGN-PC-00DWQL family 2 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 3
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 3
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
Beta-secretase 1 and Cytochrome P450 3A4 inhibitor N-[(2S,3R)-... 3 7
Peroxisome proliferator-activated receptor alpha and Peroxisom... 5 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 10 5
Peroxisome proliferator-activated receptor gamma and Peroxisom... 3 0
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 1 5
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 1
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 4
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 15
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 11 3
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-04UH7Y family 4 1
Leukotriene A-4 hydrolase inhibitor SureCN3030546 family 9 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 3
Metabotropic glutamate receptor 5 ligand SureCN504754 family 5 4
Diacylglycerol O-acyltransferase 1 inhibitor SureCN2789698 family 2 8
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 2 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 0
Prostacyclin receptor ligand 5-[[4-(3-acetamidophenyl)phenyl]m... 4 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00364967 CHEMBL299467 Bioactive SureCN8054829
CFAMM00364988 CHEMBL151519 Bioactive (E)-7-[4-[4-[[(1R,2S)-2-phenylcyclopropyl]carbamoyl]-1,3-oxazol-2-yl]phenyl]-7-pyridin-3-ylhept-6-enoic acid
CFAMM00365000 CHEMBL150563 Bioactive SureCN8055988
CFAMM00364962 CHEMBL151083 Bioactive SureCN8054807

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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