CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5626
Family Name Cathepsin S inhibitor SureCN7062841 family
No. of Seeds 7 No. of Other Members 7
Family Centroid CFAMM00365012 Functional Category Bioactive with Natural Product
Superfamily Cathepsin S Binder Superfamily 3
Class Class 1787

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Voltage-gated sodium channel Ligand Lacosamide Family 1 10
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Prothrombin Inhibitor Ppack Family 5 4
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU83876 F... 3 51
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
Melanocortin receptor 4 and Substance-K receptor Ligand Hoo-ph... 3 19
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Substance-K receptor ligand (4S)-4-amino-1-[4-(oxan-4-ylmethyl... 1 2
Disintegrin and metalloproteinase domain-containing protein 17... 7 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 5 3
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 1 8
Cathepsin S inhibitor SureCN7397817 family 9 4
Cathepsin S inhibitor N-[(2S)-1-[[(1S)-1-cyano-2-(3,4-dichloro... 1 0
Cathepsin K and Cathepsin S inhibitor 1-benzyl-3-[(2S)-1-[[cya... 1 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (2S... 16 24
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 0
Dipeptidyl peptidase 4 inhibitor (3R)-4-[(3R)-3-amino-4-(2,4,5... 6 6
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
Cathepsin S inhibitor (2R)-N-[(1R)-2-[(4-chlorophenyl)methoxy]... 2 0
Cathepsin S inhibitor (2R)-N-[(3S)-1-benzyl-3-cyanopyrrolidin-... 2 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-2-... 6 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 15 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 10 0
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor Su... 1 1
Renin inhibitor N-[(2S)-1-[[(2R)-1-[[(2S)-3-cyclohexyl-1-dimet... 3 1
Sigma non-opioid intracellular receptor 1 ligand tert-butyl N-... 1 9
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 4 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00365008 CHEMBL348679 Bioactive SureCN7567569
CFAMM00365014 CHEMBL435440 Bioactive N-[(2S)-1-[[(S)-cyano(phenyl)methyl]amino]-3-cyclohexyl-1-oxopropan-2-yl]morpholine-4-carboxamide
CFAMM00365020 CHEMBL347745 Bioactive SureCN7569230
CFAMM00365012 CHEMBL153678 Bioactive SureCN7062841
CFAMM00365019 CHEMBL153239 Bioactive N-[(2S)-1-[[(1S)-1-cyano-3-phenylpropyl]amino]-3-cyclohexyl-1-oxopropan-2-yl]morpholine-4-carboxamide
CFAMM00365011 CHEMBL345502 Bioactive N-[(1S)-2-[[(1S)-1-cyano-3-phenylpropyl]amino]-1-cyclohexyl-2-oxoethyl]morpholine-4-carboxamide
CFAMM00365010 CHEMBL150574 Bioactive N-[(2S)-1-[[(1S)-1-cyano-3-phenylpropyl]amino]-1-oxohexan-2-yl]morpholine-4-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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