CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5680
Family Name Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-[2-(3-piperazin-1-ylazetidin-1-yl)ethyl]piperidin-2-one family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00365291 Functional Category Bioactive
Superfamily Neuromedin-K receptor Ligand Osanetant Superfamily
Class Class 908

Cousin Family NamesSeedsMembers
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Neuromedin-K receptor Ligand Osanetant Family 38 192
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
Tumor necrosis factor Inhibitor Talactoferrin Alfa Family 26 131
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 1 1
Substance-K receptor and Substance-P receptor ligand N-[4-[[4-... 1 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 1 1
Substance-P receptor ligand AGN-PC-075NUD family 4 1
Substance-P receptor ligand 4-[1-[2-[1-(cyclopropylmethyl)-3-(... 10 6
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 9 0
Substance-K receptor ligand (5S)-1-(2-cyclopropylethyl)-5-(3,4... 10 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 5 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 3 0
Substance-P receptor ligand 1-(cyclohexylmethyl)-5-(3,4-dichlo... 8 1
Substance-K receptor and Substance-P receptor ligand N-[(2Z,3R... 26 4
Neuromedin-K receptor ligand (1S,2R)-1-(3,4-dichlorophenyl)-N-... 8 0
Prothrombin inhibitor AGN-PC-09QJ23 family 2 5
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 7 31
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-[... 6 0
Substance-K receptor ligand SureCN3083325 family 4 0
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... 3 3
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 6 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 6 3
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-chloro-5-... 3 1
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 4
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 6 0
Sodium-dependent dopamine transporter and Transporter inhibito... 6 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 1 1
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 9
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 1
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[(3,4-dichlo... 1 0
Neuromedin-K receptor and Substance-K receptor ligand AGN-PC-0... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00365291 CHEMBL151028 Bioactive 1-benzyl-5-(3,4-dichlorophenyl)-5-[2-(3-piperazin-1-ylazetidin-1-yl)ethyl]piperidin-2-one
CFAMM00365290 CHEMBL151356 Bioactive N-[1-[1-[2-[1-(cyclopropylmethyl)-3-(3,4-dichlorophenyl)-6-oxopiperidin-3-yl]ethyl]azetidin-3-yl]-4-phenylpiperidin-4-yl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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