CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM570
Family Name Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]-1-(3-phenylanilino)cyclohexane-1-carboxamide family
No. of Seeds 11 No. of Other Members 10
Family Centroid CFAMM00313317 Functional Category Bioactive with Natural Product
Superfamily Cathepsin K and Cathepsin L1 Binder Superfamily 2
Class Class 2417

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
Neuropeptide Y receptor type 1 Ligand BMS-193885 Family 3 11
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 11 13
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Renin Inhibitor Ro-66-1168 Family 10 30
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Fatty-acid amide hydrolase 1 Inhibitor Benzaldehyde O-4-ethoxy... 21 4
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Integrin beta-1 and Integrin alpha-4 inhibitor (3S)-3-(3,4-dim... 5 61
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 3 5
Vasopressin V1a receptor and Vasopressin V2 receptor ligand N-... 1 2
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Stromelysin-1 and 72 kDa type IV collagenase inhibitor [(2S)-2... 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 1 0
Renin inhibitor 6-[[(2R)-1-[4-[3-[(2-methoxyphenyl)methoxy]pro... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
Substance-P receptor ligand (2S,4S)-1-N-(3-chlorophenyl)-2-N-[... 5 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 1 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor N-[(1S,5aR,9... 2 2
Substance-P receptor ligand 1-[(5-amino-2-methoxyphenyl)methyl... 3 5
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Cathepsin S and Cathepsin K inhibitor arylaminoethyl amide, 7 ... 2 0
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial ... 3 3
Microsomal triglyceride transfer protein large subunit inhibit... 3 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Cathepsin S and Cathepsin K inhibitor SureCN3018173 family 2 4
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 3
Cathepsin K inhibitor (1R,2R)-N-(cyanomethyl)-2-[4-(3-methoxyp... 2 1
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(1-cyanocyclop... 4 0
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
Translocator protein inhibitor CHEMBL2332259 family 2 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-[4-[3... 2 0
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 20 23
Neuropeptide Y receptor type 1 ligand SureCN8354018 family 2 2
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 7
C-C chemokine receptor type 5 ligand dimethyl-[[4-[[7-(4-methy... 7 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 10
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZ6 family 3 6
Substance-P receptor ligand CP 141938 family 1 0
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(3-hydr... 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-00RZQT family 3 4
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
Growth hormone secretagogue receptor type 1 ligand N-[4-[(2S)-... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
fMet-Leu-Phe receptor ligand 2-[[(2S)-2-[[(2S)-2-[(4-methoxyph... 1 0
Histone deacetylase 8 and Histone deacetylase 6 inhibitor (3S)... 4 16
Protein-S-isoprenylcysteine O-methyltransferase inhibitor N-[2... 1 2
Transient receptor potential M8 protein ligand 2-(2,3-dihydro-... 1 0
Sodium channel protein type 9 subunit alpha ligand SureCN12900... 9 8
Cathepsin K inhibitor N-[2-(4-methoxyanilino)ethyl]-4-methyl-2... 1 1
Matrix metalloproteinase-9 and Metalloproteinase inhibitor 3 i... 1 3
Proteinase-activated receptor 1 ligand 2-[[2-[[2-[acetyl-[(E)-... 1 0
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 2 0
N-(4-acetamidophenyl)-2-(2,2-dimethyl-3,4-dihydrochromen-6-yl)... 1 0
4-(4-methoxyphenyl)-2,4,5,10-tetrahydro-1H-pyrrolo[3,4-c][1,5]... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00313317 CHEMBL203841 Bioactive N-[(2S)-1-(4-methoxyanilino)propan-2-yl]-1-(3-phenylanilino)cyclohexane-1-carboxamide
CFAMM00313330 CHEMBL557986 Bioactive 2-[4-[[(2S)-2-[[1-(3-phenylanilino)cyclohexanecarbonyl]amino]butyl]amino]phenoxy]acetic acid;dihydrochloride
CFAMM00313323 CHEMBL204006 Bioactive N-[(2S)-1-(4-methoxyanilino)pentan-2-yl]-1-(3-phenylanilino)cyclohexane-1-carboxamide
CFAMM00313322 CHEMBL206561 Bioactive (2S)-N-[(2S)-1-(4-methoxyanilino)propan-2-yl]-4-methyl-2-(3-phenylanilino)pentanamide
CFAMM00313315 CHEMBL383551 Bioactive tert-butyl 2-[4-[[(2S)-2-[[1-(3-phenylanilino)cyclohexanecarbonyl]amino]butyl]amino]phenoxy]acetate
CFAMM00313328 CHEMBL536741 Bioactive 2-[4-[[(2S)-2-[[(2S)-4-methyl-2-(3-phenylanilino)pentanoyl]amino]butyl]amino]phenoxy]acetic acid;dihydrochloride
CFAMM00313327 CHEMBL203832 Bioactive N-[(2S)-1-(4-methoxyanilino)hexan-2-yl]-1-(3-phenylanilino)cyclohexane-1-carboxamide
CFAMM00313326 CHEMBL264314 Bioactive N-[(2S)-1-(4-methoxyanilino)butan-2-yl]-1-(3-phenylanilino)cyclohexane-1-carboxamide
CFAMM00313325 CHEMBL202703 Bioactive tert-butyl 2-[4-[[(2S)-2-[[(2S)-4-methyl-2-(3-phenylanilino)pentanoyl]amino]butyl]amino]phenoxy]acetate
CFAMM00313318 CHEMBL203117 Bioactive (2S)-N-[(2S)-1-(4-methoxyanilino)butan-2-yl]-4-methyl-2-(3-phenylanilino)pentanamide
CFAMM00313331 CHEMBL1083675 Bioactive 2-[4-[[(2S)-2-[[1-(3-phenylanilino)cyclohexanecarbonyl]amino]butyl]amino]phenoxy]acetic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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