CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM577
Family Name Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-5-[4-(oxan-4-ylmethyl)piperazin-1-yl]-1-phenylpentan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide family
No. of Seeds 21 No. of Other Members 7
Family Centroid CFAMM00313375 Functional Category Bioactive
Superfamily Substance-K receptor Binder Superfamily
Class Class 3185

Cousin Family NamesSeedsMembers
Neuronal acetylcholine receptor subunit alpha-7 Ligand EVP-612... 1 11
Dipeptidyl peptidase 1 inhibitor (2S)-2-amino-N-[(1S)-1-cyano-... 4 3
Substance-K receptor ligand N-[1-[[(2S)-5-[4-(dimethylsulfamoy... 9 16
Growth hormone secretagogue receptor type 1 ligand SureCN76469... 4 4
Histone deacetylase 1 and Potassium voltage-gated channel subf... 4 36
Sigma non-opioid intracellular receptor 1 ligand ST50280143 fa... 3 54
Melanin-concentrating hormone receptor 1 ligand (3S)-3-[[5-(4-... 15 16
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 9 7
Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... 6 6
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 2 0
Cathepsin K inhibitor N-[(2S)-4-methyl-1-oxo-1-[(3-oxooxan-4-y... 2 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 2
Kappa-type opioid receptor ligand 2-[2-oxo-2-[(2S)-2-(pyrrolid... 2 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 5
Calpain-1 catalytic subunit and Cathepsin B inhibitor N-(4-ami... 1 0
Cholinesterase and Acetylcholinesterase inhibitor hexyl (2S)-5... 1 0
5-hydroxytryptamine receptor 1A ligand (3R)-N-(1-adamantyl)-1,... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00313357 CHEMBL1083865 Bioactive 6-methyl-N-[1-[[(2R)-1-[2-[1-(oxan-4-ylmethyl)piperidin-4-yl]ethoxy]-3-phenylpropan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide
CFAMM00313371 CHEMBL1083855 Bioactive 6-methyl-N-[1-[[(2R)-4-[4-[methyl(oxan-4-yl)amino]piperidin-1-yl]-1-phenylbutan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide
CFAMM00313377 CHEMBL1083852 Bioactive 6-methyl-N-[1-[[(2S)-5-[4-(morpholin-4-ylmethyl)piperidin-1-yl]-1-phenylpentan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide
CFAMM00313356 CHEMBL1083864 Bioactive 6-methyl-N-[1-[[(2R)-1-[[1-(oxan-4-ylmethyl)piperidin-4-yl]methoxy]-3-phenylpropan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide
CFAMM00313362 CHEMBL1083863 Bioactive 6-methyl-N-[1-[[(2S)-5-[1-(oxan-4-ylmethyl)piperidin-4-yl]-1-phenylpentan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide
CFAMM00313376 CHEMBL1083853 Bioactive 6-methyl-N-[1-[[(2R)-4-(4-morpholin-4-ylpiperidin-1-yl)-1-phenylbutan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide
CFAMM00313368 CHEMBL1084158 Bioactive 6-methyl-N-[1-[[(2S)-5-[4-(morpholine-4-carbonyl)piperazin-1-yl]-1-phenylpentan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide
CFAMM00313382 CHEMBL1083858 Bioactive 6-methyl-N-[1-[[(2R)-4-[4-(oxan-4-yl)piperazin-1-yl]-1-phenylbutan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide
CFAMM00313375 CHEMBL1083850 Bioactive 6-methyl-N-[1-[[(2S)-5-[4-(oxan-4-ylmethyl)piperazin-1-yl]-1-phenylpentan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide
CFAMM00313367 CHEMBL1084159 Bioactive 6-methyl-N-[1-[[(2S)-5-(4-morpholin-4-ylsulfonylpiperazin-1-yl)-1-phenylpentan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide
CFAMM00313381 CHEMBL1083859 Bioactive 6-methyl-N-[1-[[(2R)-1-[4-(oxan-4-ylmethyl)piperazin-1-yl]-3-phenylpropan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide
CFAMM00313360 CHEMBL1083861 Bioactive 6-methyl-N-[1-[[(E,2R)-5-[4-(oxan-4-ylmethyl)piperazin-1-yl]-1-phenylpent-3-en-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide
CFAMM00313374 CHEMBL1083851 Bioactive 6-methyl-N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)piperazin-1-yl]-1-phenylpentan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide
CFAMM00313380 CHEMBL1083878 Bioactive N-[1-[[(2S)-5-[4-(3-ethoxypropyl)piperazin-1-yl]-1-phenylpentan-2-yl]carbamoyl]cyclopentyl]-6-methyl-1-benzothiophene-2-carboxamide
CFAMM00313359 CHEMBL1083860 Bioactive 6-methyl-N-[1-[[(2S)-5-[4-(morpholine-4-carbonyl)piperidin-1-yl]-1-phenylpentan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide
CFAMM00313373 CHEMBL1083856 Bioactive 6-methyl-N-[1-[[(2S)-5-[4-[methyl(oxan-4-yl)amino]piperidin-1-yl]-1-phenylpentan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide
CFAMM00313379 CHEMBL1083879 Bioactive 6-methyl-N-[1-[[(2S)-5-[4-(oxane-4-carbonyl)piperazin-1-yl]-1-phenylpentan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide
CFAMM00313358 CHEMBL1083866 Bioactive 6-methyl-N-[1-[[(2S)-5-[4-(oxan-4-yl)piperazin-1-yl]-1-phenylpentan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide
CFAMM00313372 CHEMBL1083854 Bioactive 6-methyl-N-[1-[[(2S)-5-(4-morpholin-4-ylpiperidin-1-yl)-1-phenylpentan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide
CFAMM00313378 CHEMBL1084164 Bioactive N-[1-[[(2S)-5-[4-(N-ethyl-C-morpholin-4-ylcarbonimidoyl)piperazin-1-yl]-1-phenylpentan-2-yl]carbamoyl]cyclopentyl]-6-methyl-1-benzothiophene-2-carboxamide
CFAMM00313364 CHEMBL1083849 Bioactive N-[1-[[(2S)-5-[4-(oxan-4-ylmethyl)piperazin-1-yl]-1-phenylpentan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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