CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM578
Family Name Substance-K receptor ligand N-[1-[[(2S)-5-[4-(dimethylsulfamoyl)piperazin-1-yl]-1-phenylpentan-2-yl]carbamoyl]cyclopentyl]-6-methyl-1-benzothiophene-2-carboxamide family
No. of Seeds 9 No. of Other Members 16
Family Centroid CFAMM00313406 Functional Category Bioactive
Superfamily Substance-K receptor Binder Superfamily
Class Class 3185

Cousin Family NamesSeedsMembers
Neuronal acetylcholine receptor subunit alpha-7 Ligand EVP-612... 1 11
72 kDa type IV collagenase Inhibitor Batimastat Family 6 52
Dipeptidyl peptidase 1 inhibitor (2S)-2-amino-N-[(1S)-1-cyano-... 4 3
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-5-[4-(oxan-4-... 21 7
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 4 2
Type-1 angiotensin II receptor ligand AGN-PC-04X45B family 9 12
Growth hormone secretagogue receptor type 1 ligand (E)-5-amino... 1 1
Growth hormone secretagogue receptor type 1 ligand SureCN76469... 4 4
Histone deacetylase 1 and Potassium voltage-gated channel subf... 4 36
Sigma non-opioid intracellular receptor 1 ligand ST50280143 fa... 3 54
Gonadotropin-releasing hormone receptor ligand 3-[(2R)-2-amino... 3 1
Melanin-concentrating hormone receptor 1 ligand (3S)-3-[[5-(4-... 15 16
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 9 7
Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... 6 6
Melanin-concentrating hormone receptor 1 ligand N-methyl-4-(4-... 1 0
Growth hormone secretagogue receptor type 1 ligand (2S)-2,6-di... 2 1
Coagulation factor X inhibitor 5-chloro-N-[(1R,2S)-2-[[4-[1-(p... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 2 0
Prothrombin and Cationic trypsin inhibitor (2S)-N-[[4-[(Z)-C-a... 6 3
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-2-(butyl... 8 6
Kappa-type opioid receptor ligand 2-[2-oxo-2-[(2S)-2-(pyrrolid... 2 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 5
Calpain-1 catalytic subunit and Cathepsin B inhibitor N-(4-ami... 1 0
Carbonic anhydrase 2 inhibitor AGN-PC-07C00S family 4 1
5-hydroxytryptamine receptor 1A ligand (3R)-N-(1-adamantyl)-1,... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00313386 CHEMBL1083869 Bioactive N-[1-[[(2S)-5-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]-1-phenylpentan-2-yl]carbamoyl]cyclopentyl]-6-methyl-1-benzothiophene-2-carboxamide
CFAMM00313392 CHEMBL1083874 Bioactive 6-methyl-N-[1-[[(2S)-1-phenyl-5-[4-(thiophen-3-ylmethyl)piperazin-1-yl]pentan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide
CFAMM00313406 CHEMBL1084160 Bioactive N-[1-[[(2S)-5-[4-(dimethylsulfamoyl)piperazin-1-yl]-1-phenylpentan-2-yl]carbamoyl]cyclopentyl]-6-methyl-1-benzothiophene-2-carboxamide
CFAMM00313398 CHEMBL1084251 Bioactive N-[1-[[(2S)-5-(4-formylpiperazin-1-yl)-1-phenylpentan-2-yl]carbamoyl]cyclopentyl]-6-methyl-1-benzothiophene-2-carboxamide
CFAMM00313404 CHEMBL1083857 Bioactive N-[1-[[(2S)-5-[4-(2-hydroxyethyl)piperidin-1-yl]-1-phenylpentan-2-yl]carbamoyl]cyclopentyl]-6-methyl-1-benzothiophene-2-carboxamide
CFAMM00313403 CHEMBL1083873 Bioactive 6-methyl-N-[1-[[(2S)-1-phenyl-5-[4-(thiophen-2-ylmethyl)piperazin-1-yl]pentan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide
CFAMM00313409 CHEMBL1084163 Bioactive N-[1-[[(2S)-5-(4-ethylsulfonylpiperazin-1-yl)-1-phenylpentan-2-yl]carbamoyl]cyclopentyl]-6-methyl-1-benzothiophene-2-carboxamide
CFAMM00313408 CHEMBL1084162 Bioactive 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4-propan-2-ylsulfonylpiperazin-1-yl)pentan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide
CFAMM00313407 CHEMBL1084161 Bioactive 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4-sulfamoylpiperazin-1-yl)pentan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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