CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5784
Family Name Carbonic anhydrase 9 and Carbonic anhydrase 14 inhibitor N-[2-(3-methoxyphenyl)ethyl]-4-sulfamoylbenzamide family
No. of Seeds 6 No. of Other Members 10
Family Centroid CFAMM00350481 Functional Category Bioactive
Superfamily Carbonic anhydrase 9 and Carbonic anhydrase 2 Binder Superfamily 2
Class Class 411

Cousin Family NamesSeedsMembers
G protein-activated inward rectifier potassium channel 4 ligan... 6 9
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
ATP-sensitive inward rectifier potassium channel 10 Ligand Gli... 1 2
Zucapsacin family 7 177
Stromelysin-1 Inhibitor PG-530742 Family 4 23
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
5-hydroxytryptamine receptor Ligand Bay X3702 Family 3 12
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Histamine H3 receptor Ligand A-349821 Family 49 228
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(3,5-dimethoxyphenethyl)oleami... 5 49
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
Disintegrin and metalloproteinase domain-containing protein 17... 82 411
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Disintegrin and metalloproteinase domain-containing protein 17... 25 33
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 7
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 6 16
Matrix metalloproteinase-9 and Collagenase 3 inhibitor 4-benzy... 10 32
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 3 13
Disintegrin and metalloproteinase domain-containing protein 17... 10 39
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Leukotriene A-4 hydrolase inhibitor 3-[3-(4-benzylphenoxy)prop... 2 0
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 1 1
Integrin beta-3 and Integrin alpha-IIb inhibitor (2R)-2-(benze... 4 13
Prothrombin inhibitor N-cyclohexyl-3-[3-(diaminomethylideneami... 3 4
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 4-acety... 9 4
Collagenase 3 and Stromelysin-1 inhibitor 1-N-benzyl-3-N-hydro... 7 15
Matrix metalloproteinase-9 and Collagenase 3 inhibitor AGN-PC-... 7 12
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Neutrophil collagenase and Stromelysin-1 inhibitor 7-[[(2S)-2-... 10 9
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-075O... 14 27
Pol polyprotein inhibitor AC1LA9K7 family 7 23
Collagenase 3 and 72 kDa type IV collagenase inhibitor (5R)-N-... 7 0
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
72 kDa type IV collagenase and Collagenase 3 inhibitor (2R)-1-... 25 6
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R,4S)... 7 1
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
72 kDa type IV collagenase and Collagenase 3 inhibitor (2R,4S)... 3 0
Survival motor neuron protein and Retinal dehydrogenase 1 inhi... 2 9
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R,4Z)... 17 0
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL15... 1 2
Neprilysin inhibitor AGN-PC-047EOU family 1 0
Carbonic anhydrase 12 and Carbonic anhydrase 2 inhibitor (E)-2... 5 6
Pol polyprotein inhibitor AC1NQUJL family 10 11
Trace amine-associated receptor 1 ligand AGN-PC-09QHOK family 1 0
Macrophage metalloelastase and 72 kDa type IV collagenase inhi... 7 4
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Collagenase 3 and 72 kDa type IV collagenase inhibitor AGN-PC-... 3 5
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 3 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 3 0
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 0
Pol polyprotein inhibitor AGN-PC-075V7I family 7 1
Integrin beta-3 and Integrin alpha-IIb inhibitor [(1R)-1-(benz... 3 0
Carbonic anhydrase 7 and Carbonic anhydrase 14 inhibitor 4-(6-... 7 8
Carbonic anhydrase 2 and Carbonic anhydrase 7 inhibitor N-[2-(... 1 2
Bone morphogenetic protein 1 inhibitor benzyl N-[(4R)-4-[1,3-b... 6 25
Beta-secretase 1 and Cathepsin B inhibitor N-[(2S)-1-[[(2S,3R)... 2 1
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 0
Macrophage metalloelastase and Collagenase 3 inhibitor (2S)-N-... 2 2
Carbonic anhydrase 9 and Carbonic anhydrase 12 inhibitor 2-(4-... 3 2
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6429531 f... 2 0
Neutrophil elastase inhibitor 1-[(2S)-2-[(4-methoxyphenyl)sulf... 2 11
72 kDa type IV collagenase and Collagenase 3 inhibitor SureCN7... 5 2
Coagulation factor X and Trypsin-1 inhibitor N-[2-(3-carbamimi... 5 7
Carbonic anhydrase 9 and Carbonic anhydrase 12 inhibitor zinc;... 4 9
Carbonic anhydrase 2 and Carbonic anhydrase 9 inhibitor zinc;4... 2 5
Carbonic anhydrase 2 and Carbonic anhydrase 9 inhibitor zinc;4... 4 0
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 1-benzy... 6 2
Neutrophil collagenase and Interstitial collagenase inhibitor ... 3 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Pol polyprotein inhibitor AC1LA9KP family 1 0
72 kDa type IV collagenase and Collagenase 3 inhibitor AGN-PC-... 3 2
Carbonic anhydrase 2 inhibitor benzyl 2-[[2-[[(2S)-3-phenyl-2-... 2 9
C-C chemokine receptor type 5 ligand (4-chlorophenyl) N-[1-[(4... 2 2
Growth hormone secretagogue receptor type 1 ligand N-[4-[(2S)-... 1 0
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
72 kDa type IV collagenase and Interstitial collagenase inhibi... 2 0
Mineralocorticoid receptor ligand N-[3-[2-[cyclopropyl(methyl)... 1 0
Bone morphogenetic protein 1 inhibitor N-hydroxy-3-[[4-[(Z)-N'... 1 1
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 1 1
Caspase-3 inhibitor N-[(2-methoxyphenyl)methyl]-3-oxo-1,2-benz... 3 0
Integrin alpha-V inhibitor (2R)-3-[(2-methoxybenzoyl)amino]-2-... 1 1
Voltage-dependent N-type calcium channel subunit alpha-1B liga... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00366242 CHEMBL2048917 Bioactive N-[2-(3,4-dimethoxyphenyl)ethyl]-4-sulfamoylbenzamide
CFAMM00366267 CHEMBL2402758 Bioactive AC1NDM12
CFAMM00366266 CHEMBL1518649 Bioactive ZINC03378280

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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