CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM579
Family Name Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4-pyrimidin-2-ylpiperazin-1-yl)pentan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide family
No. of Seeds 3 No. of Other Members 9
Family Centroid CFAMM00313412 Functional Category Bioactive
Superfamily Substance-K receptor and MAP kinase-activated protein kinase 2 Binder Superfamily
Class Class 3155

Cousin Family NamesSeedsMembers
Renin Inhibitor Remikiren Family 100 126
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 3 5
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07ZDR2 f... 7 33
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor lig... 2 8
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 8 1
Thyroid hormone receptor beta and Ferritin light chain ligand ... 3 10
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QJ7P family 2 0
Gonadotropin-releasing hormone receptor ligand 1-[4-[1-[(2,6-d... 8 0
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 2
Vascular endothelial growth factor receptor 1 and Receptor-typ... 1 0
Protein kinase C zeta type and Inhibitor of nuclear factor kap... 1 6
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 15 8
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 2 2
Melanin-concentrating hormone receptor 1 and Muscarinic acetyl... 8 2
cAMP-dependent protein kinase catalytic subunit beta and cAMP-... 2 9
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 5 0
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
NAD-dependent protein deacetylase sirtuin-2 and NAD-dependent ... 8 12
Melanocortin receptor 4 ligand AGN-PC-076ANF family 1 0
High affinity nerve growth factor receptor and Hepatocyte grow... 6 8
Gastrin-releasing peptide receptor ligand (2S)-N-[(2S)-1-[[(2S... 1 0
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 20 7
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-00A4QJ family 12 6
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 5 1
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-03LEDF family 3 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00313414 CHEMBL1083867 Bioactive 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4-pyridin-2-ylpiperazin-1-yl)pentan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide
CFAMM00313419 CHEMBL1083876 Bioactive N-[1-[[(2S)-5-[4-(1H-imidazol-5-ylmethyl)piperazin-1-yl]-1-phenylpentan-2-yl]carbamoyl]cyclopentyl]-6-methyl-1-benzothiophene-2-carboxamide
CFAMM00313412 CHEMBL1083868 Bioactive 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4-pyrimidin-2-ylpiperazin-1-yl)pentan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26235 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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