CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5793
Family Name Bifunctional dihydrofolate reductase-thymidylate synthase and Dihydrofolate reductase inhibitor AC1LA0CK family
No. of Seeds 6 No. of Other Members 13
Family Centroid CFAMM00144905 Functional Category Bioactive
Superfamily Dihydrofolate reductase and Dual specificity protein kinase TTK Binder Superfamily
Class Class 831

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Histamine H1 receptor Ligand Astemizole Family 7 240
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Histamine H1 receptor Ligand Mepyramine Family 5 65
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Tyrosine-protein kinase SYK Inhibitor R788 Family 3 7
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
AP26113 family 16 90
SB1518 family 7 103
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Ibrutinib family 2 27
MK-6096 family 3 69
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
Platelet-derived growth factor receptor alpha and Platelet-der... 3 18
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Metabotropic glutamate receptor 5 Ligand 7-(4,6-dimethoxypyrim... 2 0
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Metabotropic glutamate receptor 1 Ligand 4-(cyclohexyloxy)quin... 1 4
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Adenosine receptor A1 and Adenosine receptor A2a ligand NSC658... 8 54
Dual specificity mitogen-activated protein kinase kinase 1 inh... 10 54
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Platelet-derived growth factor receptor beta and Platelet-deri... 2 19
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 2 6
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-00EQPZ fa... 3 4
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11
Proto-oncogene tyrosine-protein kinase Src and Cyclin-dependen... 2 1
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Cathepsin S and Cathepsin K inhibitor AGN-PC-088VBO family 3 11
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Epidermal growth factor receptor and Cyclin-dependent kinase 1... 3 4
Aurora kinase A inhibitor SureCN761545 family 2 2
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Aurora kinase A inhibitor AGN-PC-00BCUF family 16 43
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
Survival motor neuron protein inhibitor CHEMBL1307497 family 1 2
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 8
Prostaglandin D2 receptor ligand 3-[2-methoxy-6-[2-(4-methoxyp... 2 12
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 3
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Epidermal growth factor receptor ligand Pyrimido[4,5-b]indole ... 1 4
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... 9 32
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Proto-oncogene tyrosine-protein kinase Src and Epidermal growt... 9 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 2 0
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 3 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FPC ... 6 1
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 0
Corticotropin-releasing factor receptor 1 ligand 5-N-(2-chloro... 7 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 3
Toll-like receptor 7 ligand 4-amino-1-[[6-(2-pyrrolidin-1-ylet... 2 5
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 5 1
Platelet-derived growth factor receptor beta ligand AGN-PC-075... 3 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 4 2
Cathepsin K and Cathepsin L1 inhibitor CHEBI:43424 family 2 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-009TSL... 3 3
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 42 3
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
ALK tyrosine kinase receptor ligand CHEMBL1946804 family 3 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 5 8
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 0
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 7 3
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... 4 0
Wee1-like protein kinase and ALK tyrosine kinase receptor liga... 1 9
Receptor tyrosine-protein kinase erbB-2 and Tyrosine-protein k... 1 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
ALK tyrosine kinase receptor and Insulin-like growth factor 1 ... 1 4
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
Protein-tyrosine kinase 2-beta and Focal adhesion kinase 1 inh... 3 6
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-07... 1 0
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
Dual specificity protein kinase TTK inhibitor 2-[1-[4-[[6-(cyc... 8 0
Vascular endothelial growth factor receptor 2 and Vascular end... 4 2
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 9
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family 2 0
Focal adhesion kinase 1 inhibitor AGN-PC-00AVK6 family 1 1
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
Fibroblast growth factor receptor 1 and Vascular endothelial g... 3 0
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 6 13
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 14 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 18 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 1 1
Beta-secretase 1 and Beta-secretase 2 inhibitor 7-fluoro-3-(5-... 2 7
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Cathepsin K and Cathepsin L1 inhibitor 2-Cyano-pyrimidine, 17a... 5 8
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
Rho-associated protein kinase 1 inhibitor SureCN4716133 family 2 2
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 1
Glucose-dependent insulinotropic receptor ligand 2-[1-(5-ethyl... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Transient receptor potential cation channel subfamily V member... 2 4
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
TRAF2 and NCK-interacting protein kinase and Serine/threonine-... 2 2
TRAF2 and NCK-interacting protein kinase inhibitor 4-methoxy-3... 4 1
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 2 0
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 4 9
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Hepatocyte growth factor receptor ligand 6-[(1S)-1-[6-(2,3-dih... 1 5
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Mitogen-activated protein kinase kinase kinase 11 and Leucine-... 1 2
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Histone-lysine N-methyltransferase EHMT2 inhibitor N-(1-cyclop... 1 2
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Ephrin type-A receptor 3 and Tyrosine-protein kinase Fgr ligan... 1 3
Tyrosine-protein kinase TXK and Tyrosine-protein kinase Lyn in... 1 1
Melanin-concentrating hormone receptor 1 ligand SureCN5431614 ... 1 2
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[(5-fl... 3 2
Transient receptor potential cation channel subfamily V member... 2 0
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 2 2
Epidermal growth factor receptor ligand AGN-PC-078X8C family 10 8
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Histamine H1 receptor ligand N-[6-[2-[(4-methoxyphenyl)methyl-... 2 1
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Type-1 angiotensin II receptor ligand 2-ethyl-6-methoxy-N-[[4-... 2 0
Dihydrofolate reductase and Dihydrofolate reductase type 1 inh... 8 1
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 1 0
Adenosine kinase inhibitor SureCN8139139 family 1 1
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
Transient receptor potential cation channel subfamily V member... 18 1
Tubulin beta-4A chain and Tubulin beta-2B chain inhibitor AGN-... 1 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 4
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 1 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 3
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Vascular endothelial growth factor receptor 2 ligand pyrimidin... 2 2
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase inhibitor 1-... 1 3
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 7
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
LIM domain kinase 2 and LIM domain kinase 1 inhibitor SureCN36... 1 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-04WWHE family 2 0
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-04WVYY family 1 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 3
Epidermal growth factor receptor ligand 4-Anilinoquinazoline d... 2 0
Transient receptor potential cation channel subfamily V member... 3 2
Metabotropic glutamate receptor 5 ligand N-[2-[(3-chlorophenyl... 1 4
Serine/threonine-protein kinase ATR inhibitor 4-[2-(6-methoxy-... 1 0
Protein kinase C theta type inhibitor SureCN3953579 family 2 1
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 2 0
Serine/threonine-protein kinase PLK1 inhibitor SureCN3992071 f... 1 0
Nuclear receptor ROR-gamma and Cytochrome P450 3A4 ligand NCGC... 1 1
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 2
Vascular endothelial growth factor receptor 2 and Serine/threo... 4 2
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 3 35
Huntingtin and Nuclear receptor ROR-gamma ligand CHEMBL1324975... 1 0
Sodium channel protein type 9 subunit alpha and Sodium channel... 2 0
Casein kinase II subunit alpha inhibitor N-[3-[[8-cyano-4-(3-e... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00366305 CHEMBL310836 Bioactive 6-[(3,5-dipropoxyanilino)methyl]-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

25238 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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