| Cousin Family Names | Seeds | Members |
|---|
| DNA Binder Primaquine Family | 3 | 245 |
| Alpha-1D adrenergic receptor Ligand Terazosin Family | 28 | 638 |
| Histamine H1 receptor Ligand Astemizole Family | 7 | 240 |
| Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family | 4 | 311 |
| Epidermal growth factor receptor Ligand Gefitinib Family | 26 | 600 |
| Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family | 67 | 482 |
| cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... | 53 | 741 |
| Histamine H1 receptor Ligand Mepyramine Family | 5 | 65 |
| Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family | 8 | 265 |
| Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... | 23 | 121 |
| Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... | 29 | 421 |
| Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family | 7 | 107 |
| Tyrosine-protein kinase SYK Inhibitor R788 Family | 3 | 7 |
| Hepatocyte growth factor receptor and Vascular endothelial gro... | 28 | 178 |
| Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... | 4 | 180 |
| Vascular endothelial growth factor receptor 2 Ligand Cediranib... | 8 | 38 |
| Insulin-like growth factor 1 receptor Ligand AEW-541 Family | 12 | 140 |
| Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... | 25 | 40 |
| Corticotropin-releasing factor receptor 1 Ligand GW876008 Family | 3 | 30 |
| AP26113 family | 16 | 90 |
| SB1518 family | 7 | 103 |
| Hepatocyte growth factor receptor Ligand Amg 208 Family | 20 | 236 |
| RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... | 7 | 148 |
| Ibrutinib family | 2 | 27 |
| MK-6096 family | 3 | 69 |
| Peptide deformylase, mitochondrial Inhibitor Epiroprim Family | 5 | 68 |
| Tyrosine kinase Inhibitor PKI166 Family | 17 | 198 |
| 5-hydroxytryptamine receptor 1A Ligand P-MPPI Family | 33 | 81 |
| Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... | 5 | 83 |
| Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... | 4 | 37 |
| Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... | 5 | 61 |
| Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... | 13 | 22 |
| Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... | 3 | 64 |
| Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... | 10 | 35 |
| Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family | 30 | 170 |
| Platelet-derived growth factor receptor alpha and Platelet-der... | 2 | 9 |
| Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... | 7 | 128 |
| Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... | 19 | 48 |
| Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... | 3 | 23 |
| Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... | 3 | 12 |
| Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... | 3 | 34 |
| Platelet-derived growth factor receptor alpha and Fibroblast g... | 3 | 47 |
| Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... | 12 | 30 |
| Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family | 5 | 22 |
| Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... | 6 | 15 |
| Potassium voltage-gated channel subfamily H member 2 Ligand Be... | 22 | 56 |
| Platelet-derived growth factor receptor alpha and Platelet-der... | 3 | 18 |
| Reverse transcriptase Inhibitor UK-129485 Family | 23 | 221 |
| 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... | 17 | 49 |
| Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... | 1 | 11 |
| Metabotropic glutamate receptor 5 Ligand 7-(4,6-dimethoxypyrim... | 2 | 0 |
| Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... | 4 | 20 |
| Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... | 2 | 7 |
| Metabotropic glutamate receptor 1 Ligand 4-(cyclohexyloxy)quin... | 1 | 4 |
| cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... | 5 | 83 |
| Adenosine receptor A1 and Adenosine receptor A2a ligand NSC658... | 8 | 54 |
| Dual specificity mitogen-activated protein kinase kinase 1 inh... | 10 | 54 |
| Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... | 2 | 22 |
| Sodium-dependent serotonin transporter and 5-hydroxytryptamine... | 3 | 4 |
| Platelet-derived growth factor receptor beta and Platelet-deri... | 2 | 19 |
| Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... | 6 | 35 |
| Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... | 8 | 45 |
| Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... | 17 | 18 |
| Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... | 3 | 4 |
| Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... | 1 | 15 |
| Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... | 2 | 6 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... | 2 | 28 |
| Vascular endothelial growth factor receptor 2 and Angiopoietin... | 2 | 11 |
| Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... | 6 | 7 |
| Aurora kinase A and Aurora kinase B inhibitor AGN-PC-00EQPZ fa... | 3 | 4 |
| Histamine H4 receptor ligand AGN-PC-07ZG9H family | 4 | 4 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 6 | 11 |
| Proto-oncogene tyrosine-protein kinase Src and Cyclin-dependen... | 2 | 1 |
| Adenosine receptor A3 ligand AGN-PC-07N4XZ family | 4 | 11 |
| 3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... | 10 | 4 |
| Hepatocyte growth factor receptor and Receptor-type tyrosine-p... | 12 | 26 |
| Adenosine receptor A3 ligand CHEMBL1834696 family | 5 | 18 |
| 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... | 3 | 3 |
| Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family | 12 | 1 |
| Bifunctional dihydrofolate reductase-thymidylate synthase and ... | 2 | 3 |
| Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... | 4 | 27 |
| Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... | 2 | 16 |
| Cathepsin S and Cathepsin K inhibitor AGN-PC-088VBO family | 3 | 11 |
| Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... | 2 | 11 |
| Epidermal growth factor receptor and Cyclin-dependent kinase 1... | 3 | 4 |
| Aurora kinase A inhibitor SureCN761545 family | 2 | 2 |
| Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... | 3 | 19 |
| Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... | 5 | 11 |
| Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... | 2 | 5 |
| Aurora kinase A inhibitor AGN-PC-00BCUF family | 16 | 43 |
| cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... | 19 | 11 |
| Survival motor neuron protein inhibitor CHEMBL1307497 family | 1 | 2 |
| Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... | 8 | 8 |
| cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... | 8 | 12 |
| DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... | 1 | 3 |
| D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... | 2 | 8 |
| Prostaglandin D2 receptor ligand 3-[2-methoxy-6-[2-(4-methoxyp... | 2 | 12 |
| Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... | 1 | 7 |
| Dihydrofolate reductase and Bifunctional dihydrofolate reducta... | 3 | 10 |
| Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... | 1 | 2 |
| Cellular tumor antigen p53 inhibitor CHEMBL1401545 family | 1 | 25 |
| D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... | 3 | 14 |
| Thyroid hormone receptor beta and Ferritin light chain ligand ... | 1 | 35 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... | 3 | 20 |
| Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... | 6 | 9 |
| Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... | 2 | 1 |
| D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... | 5 | 4 |
| Dihydrofolate reductase inhibitor AC1LA5HU family | 8 | 4 |
| Dihydrofolate reductase and Bifunctional dihydrofolate reducta... | 3 | 3 |
| Dihydrofolate reductase inhibitor AC1L9XPA family | 6 | 5 |
| Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... | 1 | 6 |
| Epidermal growth factor receptor ligand Pyrimido[4,5-b]indole ... | 1 | 4 |
| Lethal factor and Dual specificity protein kinase CLK4 inhibit... | 1 | 3 |
| Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... | 9 | 32 |
| Inositol monophosphatase 1 inhibitor CHEMBL1588383 family | 1 | 6 |
| Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... | 2 | 11 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 2 | 0 |
| D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... | 3 | 6 |
| Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... | 2 | 9 |
| cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... | 2 | 4 |
| Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... | 4 | 12 |
| Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... | 2 | 5 |
| Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... | 6 | 16 |
| Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... | 2 | 2 |
| 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... | 1 | 0 |
| Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... | 1 | 0 |
| Adenosine receptor A3 ligand AGN-PC-08WSLM family | 5 | 22 |
| Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... | 6 | 8 |
| Proto-oncogene tyrosine-protein kinase Src and Epidermal growt... | 9 | 9 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 2 | 2 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 6 | 12 |
| Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... | 3 | 17 |
| Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... | 2 | 0 |
| Insulin-like growth factor 1 receptor ligand 3qqu family | 2 | 12 |
| Ephrin type-B receptor 4 ligand SureCN5131922 family | 4 | 0 |
| Ephrin type-B receptor 4 and Vascular endothelial growth facto... | 2 | 0 |
| Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family | 8 | 8 |
| Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... | 5 | 5 |
| Melatonin receptor type 1B ligand CHEMBL1802020 family | 2 | 7 |
| Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... | 9 | 10 |
| Insulin receptor and Insulin-like growth factor 1 receptor lig... | 17 | 7 |
| Insulin-like growth factor 1 receptor and Potassium voltage-ga... | 2 | 2 |
| Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... | 3 | 1 |
| Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FPC ... | 6 | 1 |
| Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... | 11 | 27 |
| ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... | 8 | 0 |
| Corticotropin-releasing factor receptor 1 ligand 5-N-(2-chloro... | 7 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... | 2 | 2 |
| TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... | 5 | 2 |
| Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... | 1 | 3 |
| Toll-like receptor 7 ligand 4-amino-1-[[6-(2-pyrrolidin-1-ylet... | 2 | 5 |
| Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... | 5 | 1 |
| Platelet-derived growth factor receptor beta ligand AGN-PC-075... | 3 | 0 |
| Corticotropin-releasing factor receptor 1 and Corticotropin-re... | 4 | 2 |
| Cathepsin K and Cathepsin L1 inhibitor CHEBI:43424 family | 2 | 0 |
| Corticotropin-releasing factor receptor 1 ligand AGN-PC-009TSL... | 3 | 3 |
| Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... | 2 | 7 |
| Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... | 4 | 9 |
| Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... | 2 | 0 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 3 | 2 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 2 | 0 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 6 | 0 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 8 | 1 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 3 | 1 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 10 | 4 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 5 | 0 |
| cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... | 42 | 3 |
| Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... | 5 | 7 |
| Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... | 3 | 1 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 8 | 2 |
| Vascular endothelial growth factor receptor 3 and Platelet-der... | 8 | 13 |
| Platelet-derived growth factor receptor beta and Receptor-type... | 5 | 1 |
| ALK tyrosine kinase receptor ligand CHEMBL1946804 family | 3 | 0 |
| Corticotropin-releasing factor receptor 1 and Corticotropin-re... | 2 | 1 |
| Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... | 5 | 8 |
| Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... | 5 | 2 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 8 | 3 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 8 | 0 |
| Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... | 4 | 0 |
| Insulin-like growth factor 1 receptor ligand GSK1220512A family | 20 | 15 |
| Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... | 1 | 0 |
| Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... | 5 | 2 |
| Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... | 7 | 3 |
| Macrophage colony-stimulating factor 1 receptor and Ephrin typ... | 1 | 0 |
| Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... | 4 | 0 |
| Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... | 8 | 1 |
| Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... | 4 | 0 |
| Wee1-like protein kinase and ALK tyrosine kinase receptor liga... | 1 | 9 |
| Receptor tyrosine-protein kinase erbB-2 and Tyrosine-protein k... | 1 | 0 |
| Rho-associated protein kinase 1 and cAMP-dependent protein kin... | 1 | 11 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 3 | 6 |
| ALK tyrosine kinase receptor and Insulin-like growth factor 1 ... | 1 | 4 |
| Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... | 9 | 3 |
| Protein-tyrosine kinase 2-beta and Focal adhesion kinase 1 inh... | 3 | 6 |
| Vascular endothelial growth factor receptor 2 and Aurora kinas... | 4 | 3 |
| Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-07... | 1 | 0 |
| Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... | 12 | 2 |
| Dual specificity protein kinase TTK inhibitor 2-[1-[4-[[6-(cyc... | 8 | 0 |
| Vascular endothelial growth factor receptor 2 and Vascular end... | 4 | 2 |
| Bifunctional dihydrofolate reductase-thymidylate synthase and ... | 7 | 16 |
| Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... | 2 | 9 |
| Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family | 2 | 0 |
| Focal adhesion kinase 1 inhibitor AGN-PC-00AVK6 family | 1 | 1 |
| Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... | 5 | 0 |
| Fibroblast growth factor receptor 1 and Vascular endothelial g... | 3 | 0 |
| D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... | 2 | 2 |
| Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... | 6 | 13 |
| Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... | 14 | 2 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 2 | 2 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 18 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 4 | 0 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 4 | 0 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 3 | 0 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 1 | 1 |
| Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... | 1 | 1 |
| Beta-secretase 1 and Beta-secretase 2 inhibitor 7-fluoro-3-(5-... | 2 | 7 |
| Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... | 1 | 0 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 2 | 0 |
| Cathepsin K and Cathepsin L1 inhibitor 2-Cyano-pyrimidine, 17a... | 5 | 8 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 3 | 1 |
| Rho-associated protein kinase 1 inhibitor SureCN4716133 family | 2 | 2 |
| Angiopoietin-1 receptor and Vascular endothelial growth factor... | 4 | 8 |
| Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... | 4 | 3 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 4 | 1 |
| Glucose-dependent insulinotropic receptor ligand 2-[1-(5-ethyl... | 2 | 1 |
| Angiopoietin-1 receptor and Vascular endothelial growth factor... | 4 | 6 |
| Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... | 2 | 0 |
| Vascular endothelial growth factor receptor 2 and Serine/threo... | 6 | 13 |
| Corticotropin-releasing factor receptor 1 and Corticotropin-re... | 3 | 14 |
| Transient receptor potential cation channel subfamily V member... | 2 | 4 |
| Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... | 3 | 2 |
| TRAF2 and NCK-interacting protein kinase and Serine/threonine-... | 2 | 2 |
| TRAF2 and NCK-interacting protein kinase inhibitor 4-methoxy-3... | 4 | 1 |
| Mast/stem cell growth factor receptor Kit and Epithelial disco... | 3 | 0 |
| Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... | 5 | 2 |
| Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... | 2 | 0 |
| Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... | 2 | 8 |
| Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... | 8 | 5 |
| Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... | 4 | 4 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... | 4 | 0 |
| Mitogen-activated protein kinase 8 and Mitogen-activated prote... | 4 | 9 |
| 5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... | 2 | 2 |
| 5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... | 2 | 1 |
| Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... | 8 | 1 |
| Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... | 2 | 0 |
| Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... | 2 | 1 |
| Hepatocyte growth factor receptor ligand 6-[(1S)-1-[6-(2,3-dih... | 1 | 5 |
| Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... | 2 | 5 |
| Mitogen-activated protein kinase kinase kinase 11 and Leucine-... | 1 | 2 |
| Vascular endothelial growth factor receptor 2 and Angiopoietin... | 3 | 3 |
| Histone-lysine N-methyltransferase EHMT2 inhibitor N-(1-cyclop... | 1 | 2 |
| Angiopoietin-1 receptor and Vascular endothelial growth factor... | 5 | 0 |
| Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... | 5 | 0 |
| Ephrin type-A receptor 3 and Tyrosine-protein kinase Fgr ligan... | 1 | 3 |
| Tyrosine-protein kinase TXK and Tyrosine-protein kinase Lyn in... | 1 | 1 |
| Melanin-concentrating hormone receptor 1 ligand SureCN5431614 ... | 1 | 2 |
| Cathepsin K and Cathepsin S inhibitor SureCN4135077 family | 2 | 0 |
| Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... | 2 | 2 |
| C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[(5-fl... | 3 | 2 |
| Transient receptor potential cation channel subfamily V member... | 2 | 0 |
| Tyrosine-protein kinase Lck and Vascular endothelial growth fa... | 2 | 2 |
| Epidermal growth factor receptor ligand AGN-PC-078X8C family | 10 | 8 |
| Epidermal growth factor receptor ligand SureCN2989664 family | 5 | 2 |
| Histamine H1 receptor ligand N-[6-[2-[(4-methoxyphenyl)methyl-... | 2 | 1 |
| Dihydrofolate reductase inhibitor AC1LAPW3 family | 3 | 0 |
| Bifunctional dihydrofolate reductase-thymidylate synthase inhi... | 2 | 6 |
| Dihydrofolate reductase inhibitor AGN-PC-001U7R family | 3 | 0 |
| Vascular endothelial growth factor receptor 2 and Vascular end... | 1 | 1 |
| Type-1 angiotensin II receptor ligand 2-ethyl-6-methoxy-N-[[4-... | 2 | 0 |
| Dihydrofolate reductase and Dihydrofolate reductase type 1 inh... | 8 | 1 |
| Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... | 9 | 0 |
| Tyrosine-protein kinase Lck and Vascular endothelial growth fa... | 1 | 0 |
| Adenosine kinase inhibitor SureCN8139139 family | 1 | 1 |
| Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family | 2 | 0 |
| Transient receptor potential cation channel subfamily V member... | 18 | 1 |
| Tubulin beta-4A chain and Tubulin beta-2B chain inhibitor AGN-... | 1 | 0 |
| Vascular endothelial growth factor receptor 2 ligand 2-aminobe... | 1 | 0 |
| Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... | 2 | 3 |
| Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... | 4 | 4 |
| Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... | 1 | 3 |
| Bifunctional dihydrofolate reductase-thymidylate synthase and ... | 1 | 3 |
| Insulin-like growth factor 1 receptor ligand SureCN311483 family | 3 | 0 |
| Vascular endothelial growth factor receptor 2 ligand pyrimidin... | 2 | 2 |
| Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... | 4 | 0 |
| Insulin-like growth factor 1 receptor and Mitogen-activated pr... | 15 | 1 |
| Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... | 4 | 0 |
| 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase inhibitor 1-... | 1 | 3 |
| Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... | 7 | 5 |
| Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... | 4 | 3 |
| Adenosine receptor A2a ligand AGN-PC-077RYH family | 16 | 5 |
| Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... | 3 | 8 |
| Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family | 4 | 2 |
| Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... | 3 | 5 |
| 5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... | 2 | 0 |
| cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... | 3 | 1 |
| Epidermal growth factor receptor and Receptor tyrosine-protein... | 3 | 7 |
| Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... | 3 | 1 |
| cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... | 7 | 6 |
| 5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... | 6 | 1 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 2 | 0 |
| LIM domain kinase 2 and LIM domain kinase 1 inhibitor SureCN36... | 1 | 1 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 2 | 0 |
| TGF-beta receptor type-1 ligand SureCN373216 family | 3 | 14 |
| Tyrosine-protein kinase JAK2 inhibitor AGN-PC-04WWHE family | 2 | 0 |
| Tyrosine-protein kinase JAK2 inhibitor AGN-PC-04WVYY family | 1 | 0 |
| Dihydrofolate reductase and Bifunctional dihydrofolate reducta... | 1 | 0 |
| Bifunctional dihydrofolate reductase-thymidylate synthase and ... | 1 | 3 |
| Epidermal growth factor receptor ligand 4-Anilinoquinazoline d... | 2 | 0 |
| Transient receptor potential cation channel subfamily V member... | 3 | 2 |
| Metabotropic glutamate receptor 5 ligand N-[2-[(3-chlorophenyl... | 1 | 4 |
| Serine/threonine-protein kinase ATR inhibitor 4-[2-(6-methoxy-... | 1 | 0 |
| Protein kinase C theta type inhibitor SureCN3953579 family | 2 | 1 |
| Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... | 2 | 0 |
| Serine/threonine-protein kinase PLK1 inhibitor SureCN3992071 f... | 1 | 0 |
| Nuclear receptor ROR-gamma and Cytochrome P450 3A4 ligand NCGC... | 1 | 1 |
| Bifunctional dihydrofolate reductase-thymidylate synthase and ... | 1 | 2 |
| Vascular endothelial growth factor receptor 2 and Serine/threo... | 4 | 2 |
| Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... | 3 | 35 |
| Huntingtin and Nuclear receptor ROR-gamma ligand CHEMBL1324975... | 1 | 0 |
| Sodium channel protein type 9 subunit alpha and Sodium channel... | 2 | 0 |
| Casein kinase II subunit alpha inhibitor N-[3-[[8-cyano-4-(3-e... | 2 | 0 |
| cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... | 2 | 0 |
Statistics of CFAM Database |
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
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How to cite our database |
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C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
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Last update by |
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2014.08.29
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