CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5851
Family Name D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]-3-methoxybenzamide family
No. of Seeds 7 No. of Other Members 9
Family Centroid CFAMM00178605 Functional Category Bioactive
Superfamily D(4) dopamine receptor and D(3) dopamine receptor Binder Superfamily 2
Class Class 1458

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand phenylpiperazine derivative Arip... 3 53
D(2) dopamine receptor Ligand Nemonapride Family 70 283
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Tubulin Inhibitor WR85915 Family 3 15
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Sodium channel protein type 10 subunit alpha and Sodium channe... 2 13
Urotensin-2 receptor Ligand SB-436811 Family 6 71
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
Metabotropic glutamate receptor 5 Ligand N-(3-(3-cyanobenzamid... 2 13
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 11 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
D(3) dopamine receptor and D(1A) dopamine receptor ligand N-[(... 6 14
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Prelamin-A/C and Cruzipain inhibitor CHEMBL1598118 family 1 3
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 2 0
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (2R... 8 9
Receptor-type tyrosine-protein kinase FLT3 ligand (3Z)-5-chlor... 1 4
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-chloro-5-... 3 0
Bifunctional epoxide hydrolase 2 and RAF proto-oncogene serine... 4 10
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-fluoro-5-hydro... 2 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
D(3) dopamine receptor and D(4) dopamine receptor ligand SureC... 3 19
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Growth hormone secretagogue receptor type 1 ligand N-[4-[(2S)-... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 1 1
4-(4-methoxyphenyl)-2,4,5,10-tetrahydro-1H-pyrrolo[3,4-c][1,5]... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00368266 CHEMBL2165118 Bioactive 7-[3-[4-(2,3-dichlorophenyl)-1,4-diazepan-1-yl]propoxy]-3,4-dihydro-2H-isoquinolin-1-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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