CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM590
Family Name Potassium voltage-gated channel subfamily H member 2 and Neuronal acetylcholine receptor subunit alpha-7 ligand (1S,4S)-2-[5-(1-benzothiophen-5-yl)pyrazin-2-yl]-5-methyl-2,5-diazabicyclo[2.2.1]heptane family
No. of Seeds 2 No. of Other Members 3
Family Centroid CFAMM00313490 Functional Category Bioactive
Superfamily Neuronal acetylcholine receptor subunit alpha-7 and Potassium voltage-gated channel subfamily H member 2 Binder Superfamily
Class Class 3083

Cousin Family NamesSeedsMembers
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor 1-(1-(4-thi... 3 36
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 11 20
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
D(2) dopamine receptor Ligand PD-135146 Family 5 11
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
NADH-ubiquinone oxidoreductase chain 3 Inhibitor 6-thiophen-3-... 2 0
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZXHN fa... 2 4
Alpha-1B adrenergic receptor and Alpha-1A adrenergic receptor ... 1 2
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Platelet-activating factor receptor ligand Foropafant family 2 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 1 0
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
Mitogen-activated protein kinase 14 inhibitor 303163-37-3 family 1 2
Alpha-1A adrenergic receptor and Alpha-2A adrenergic receptor ... 1 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand 3-(1-... 1 0
Cytochrome P450 11B1, mitochondrial and Cytochrome P450 11B2, ... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00313490 CHEMBL1084022 Bioactive (1S,4S)-2-[5-(1-benzothiophen-5-yl)pyrazin-2-yl]-5-methyl-2,5-diazabicyclo[2.2.1]heptane
CFAMM00313494 CHEMBL1085806 Bioactive (1S,4S)-2-[5-(1-benzothiophen-5-yl)pyrimidin-2-yl]-5-methyl-2,5-diazabicyclo[2.2.1]heptane

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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