CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6038
Family Name Substance-P receptor ligand (2S,4S)-1-N-(3-chlorophenyl)-2-N-[2-[(2-methoxyphenyl)methyl-methylamino]ethyl]-4-N,4-N-dipentyl-1-N-phenylpiperidine-1,2,4-tricarboxamide family
No. of Seeds 5 No. of Other Members 2
Family Centroid CFAMM00369513 Functional Category Bioactive
Superfamily Substance-P receptor and Cathepsin S Binder Superfamily
Class Class 1104

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Substance-K receptor Ligand MEN-14933 Family 13 154
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Renin Inhibitor Ro-66-1168 Family 10 30
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Integrin beta-1 and Integrin alpha-4 inhibitor (3S)-3-(3,4-dim... 5 61
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Renin inhibitor 6-[[(2R)-1-[4-[3-[(2-methoxyphenyl)methoxy]pro... 3 1
Survival motor neuron protein and Alpha-galactosidase A inhibi... 1 4
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 1 0
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Renin and Cytochrome P450 3A4 inhibitor SureCN6719989 family 2 0
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Melanin-concentrating hormone receptor 1 ligand 3-[4-fluoro-3-... 3 7
Furin inhibitor phenyl 2-[[(2S)-1-[[(2S)-1-[[(2S)-1-(4-carbami... 2 5
Melanocortin receptor 4 ligand 3-amino-N-[(2R)-3-(2,4-dichloro... 1 9
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-(3,5-... 1 0
Neuropeptide Y receptor type 1 ligand SureCN8354018 family 2 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 7
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-00RZQT family 3 4
Histone deacetylase 8 and Histone deacetylase 6 inhibitor (3S)... 4 16
Neuropeptide Y receptor type 5 ligand SureCN3380276 family 1 1
D(2) dopamine receptor and D(3) dopamine receptor ligand 1-(3-... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00369511 CHEMBL153976 Bioactive (2S,4S)-2-N-[2-[(2-amino-2-oxoethyl)-[(2-methoxyphenyl)methyl]amino]ethyl]-4-N,4-N-dipentyl-1-N,1-N-diphenylpiperidine-1,2,4-tricarboxamide
CFAMM00369517 CHEMBL349113 Bioactive (2S,4S)-2-N-[2-[(2-amino-2-oxoethyl)-[(2-methoxyphenyl)methyl]amino]ethyl]-1-N-(3-chlorophenyl)-4-N,4-N-dipentyl-1-N-phenylpiperidine-1,2,4-tricarboxamide
CFAMM00369515 CHEMBL358173 Bioactive (2S,4S)-2-N-[2-[(2-methoxyphenyl)methyl-methylamino]ethyl]-4-N,4-N-dipentyl-1-N,1-N-diphenylpiperidine-1,2,4-tricarboxamide
CFAMM00369513 CHEMBL347891 Bioactive (2S,4S)-1-N-(3-chlorophenyl)-2-N-[2-[(2-methoxyphenyl)methyl-methylamino]ethyl]-4-N,4-N-dipentyl-1-N-phenylpiperidine-1,2,4-tricarboxamide
CFAMM00369512 CHEMBL345520 Bioactive (2S,4S)-4-N,4-N-dibenzyl-1-N-(3-chlorophenyl)-2-N-[2-[(2-methoxyphenyl)methyl-methylamino]ethyl]-1-N-phenylpiperidine-1,2,4-tricarboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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