CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6113
Family Name Stromelysin-1 and Matrix metalloproteinase-9 inhibitor AGN-PC-0759IO family
No. of Seeds 26 No. of Other Members 12
Family Centroid CFAMM00352738 Functional Category Bioactive
Superfamily Matrix metalloproteinase-9 and Disintegrin Binder Superfamily 2
Class Class 3938

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Zucapsacin family 7 177
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Substance-P receptor Ligand Ezlopitant Family 10 207
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Disintegrin and metalloproteinase domain-containing protein 17... 82 411
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 7
Matrix metalloproteinase-9 and Collagenase 3 inhibitor 4-benzy... 10 32
Disintegrin and metalloproteinase domain-containing protein 17... 10 39
Collagenase 3 and Stromelysin-1 inhibitor 1-N-benzyl-3-N-hydro... 7 15
Matrix metalloproteinase-9 and Collagenase 3 inhibitor AGN-PC-... 7 12
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Neutrophil collagenase and Stromelysin-1 inhibitor 7-[[(2S)-2-... 10 9
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-075O... 14 27
Collagenase 3 and 72 kDa type IV collagenase inhibitor (5R)-N-... 7 0
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Neutrophil collagenase inhibitor (3R)-2-[4-[4-(dimethylamino)p... 2 4
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R,4S)... 7 1
Matrix metalloproteinase-15 and Matrix metalloproteinase-16 in... 1 0
Macrophage metalloelastase and 72 kDa type IV collagenase inhi... 7 4
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 3
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 3 2
Disintegrin and metalloproteinase domain-containing protein 17... 25 5
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 7 4
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-[cyano-(2-meth... 1 0
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 1-benzy... 6 2
Neutrophil collagenase and Interstitial collagenase inhibitor ... 3 0
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(3S)-2... 2 2
Histone deacetylase 8 and Histone deacetylase 6 inhibitor (3S)... 4 16
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00E... 1 2
Dipeptidyl peptidase 4 inhibitor 7-[(3R)-3-amino-4-(2,4,5-trif... 2 0
Beta-lactamase and Histone-lysine N-methyltransferase 2A inhib... 1 7


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00369931 CHEMBL173846 Bioactive AGN-PC-0758WY
CFAMM00369944 CHEMBL368857 Bioactive AGN-PC-0759EQ
CFAMM00369957 CHEMBL155134 Bioactive (3R)-N-hydroxy-2-[(4-methoxyphenyl)-(4,4,4-trifluorobutoxy)phosphoryl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00369950 CHEMBL174315 Bioactive AGN-PC-00F1ZH
CFAMM00369943 CHEMBL347440 Bioactive (3R)-N-hydroxy-2-[(4-methoxyphenyl)-(2,2,2-trifluoroethoxy)phosphoryl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00369949 CHEMBL355797 Bioactive AGN-PC-0758UJ
CFAMM00369942 CHEMBL190713 Bioactive (3R)-N-hydroxy-2-[(4-methoxyphenyl)-[2-(4-phenylphenyl)ethoxy]phosphoryl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00369955 CHEMBL64689 Bioactive (3R)-N-hydroxy-2-[(4-methoxyphenyl)-(3,3,3-trifluoropropoxy)phosphoryl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00369948 CHEMBL192121 Bioactive (3R)-2-[cyclohexylmethoxy-(4-methoxyphenyl)phosphoryl]-N-hydroxy-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00369954 CHEMBL189690 Bioactive (3R)-2-[ethoxy-(4-phenoxyphenyl)phosphoryl]-N-hydroxy-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00369934 CHEMBL154706 Bioactive (3R)-2-[2-fluoroethoxy-(4-methoxyphenyl)phosphoryl]-N-hydroxy-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00369947 CHEMBL363424 Bioactive (3R)-2-[ethoxy-(4-methoxyphenyl)phosphoryl]-N-hydroxy-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00369927 CHEMBL425316 Bioactive AGN-PC-0758VH
CFAMM00369940 CHEMBL406939 Bioactive (3R)-N-hydroxy-2-[(4-methoxyphenyl)-(3,3,3-trifluoropropoxy)phosphoryl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00369933 CHEMBL193124 Bioactive (3R)-N-hydroxy-2-[methoxy-(4-methoxyphenyl)phosphoryl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00369952 CHEMBL173754 Bioactive AGN-PC-0758WW
CFAMM00369932 CHEMBL372470 Bioactive (3R)-2-[cyclohexyloxy-(4-methoxyphenyl)phosphoryl]-N-hydroxy-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00369945 CHEMBL435462 Bioactive (3R)-2-[2,2-difluoroethoxy-(4-methoxyphenyl)phosphoryl]-N-hydroxy-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00369958 CHEMBL190621 Bioactive (3R)-2-[[4-(4-aminophenoxy)phenyl]-ethoxyphosphoryl]-N-hydroxy-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00369951 CHEMBL370032 Bioactive (3R)-2-[2-ethoxyethoxy-(4-methoxyphenyl)phosphoryl]-N-hydroxy-3,4-dihydro-1H-isoquinoline-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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