Cousin Family Names | Seeds | Members |
---|
Cysteinyl leukotriene receptor 1 Ligand Zafirlukast Family | 48 | 78 |
DNA Binder Primaquine Family | 3 | 245 |
Melatonin receptor type 1A Ligand Melatonin Family | 20 | 988 |
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... | 2 | 136 |
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... | 28 | 2712 |
Cyclooxygenase Inhibitor Indomethacin Family | 6 | 271 |
Phospholipase A2, membrane associated Inhibitor Varespladib Fa... | 37 | 190 |
Multidrug resistance protein Inhibitor Tariquidar Family | 3 | 60 |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor GSK2... | 15 | 18 |
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... | 3 | 284 |
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... | 7 | 17 |
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... | 12 | 197 |
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... | 4 | 42 |
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... | 3 | 21 |
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... | 37 | 265 |
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... | 21 | 194 |
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... | 12 | 81 |
5-hydroxytryptamine receptor 1B Ligand GR55562 Family | 3 | 45 |
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... | 13 | 22 |
Platelet-derived growth factor receptor alpha and Platelet-der... | 2 | 17 |
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... | 9 | 80 |
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... | 1 | 16 |
Integrin beta-3 Inhibitor L-756568 Family | 8 | 59 |
Cannabinoid receptor 2 Ligand JWH-202 Family | 9 | 172 |
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... | 12 | 52 |
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... | 6 | 292 |
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... | 3 | 85 |
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family | 4 | 70 |
Platelet-derived growth factor receptor alpha and Platelet-der... | 4 | 54 |
Platelet-derived growth factor receptor alpha and Platelet-der... | 2 | 13 |
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... | 14 | 214 |
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... | 14 | 33 |
Metabotropic glutamate receptor 1 Ligand JNJ-16259685 Family | 3 | 20 |
MO15-related protein kinase Pfmrk Inhibitor WR-289010 Family | 2 | 506 |
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... | 2 | 11 |
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... | 9 | 69 |
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... | 53 | 320 |
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... | 5 | 75 |
Aromatase Inhibitor MR-16089 Family | 1 | 0 |
Reverse transcriptase Inhibitor Atevirdine Family | 4 | 55 |
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family | 8 | 44 |
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family | 7 | 34 |
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... | 18 | 72 |
Acetylcholinesterase Inhibitor Lysicamine Family | 2 | 8 |
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... | 22 | 57 |
Melatonin receptor type 1B and Melatonin receptor type 1A liga... | 3 | 16 |
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... | 7 | 44 |
Neuromedin-K receptor and Substance-K receptor ligand 2-[2-phe... | 2 | 2 |
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... | 1 | 0 |
Cannabinoid receptor 1 and 5-hydroxytryptamine receptor 1A lig... | 2 | 12 |
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... | 2 | 30 |
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... | 7 | 11 |
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... | 4 | 41 |
Disintegrin and metalloproteinase domain-containing protein 17... | 2 | 8 |
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... | 1 | 18 |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 11 | 391 |
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... | 10 | 4 |
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... | 3 | 28 |
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... | 14 | 48 |
Muscarinic acetylcholine receptor M2 and Acetylcholinesterase ... | 4 | 24 |
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... | 2 | 7 |
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... | 8 | 32 |
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... | 8 | 21 |
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... | 2 | 5 |
Renin inhibitor SureCN1144364 family | 3 | 15 |
Vascular endothelial growth factor receptor 2 and Aurora kinas... | 3 | 3 |
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... | 4 | 14 |
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... | 18 | 32 |
Histamine H3 receptor ligand AGN-PC-00BG7Z family | 11 | 49 |
Histamine H3 receptor ligand (4S)-7-bromo-4-methyl-8-(1-propan... | 2 | 0 |
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... | 10 | 50 |
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... | 4 | 6 |
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... | 2 | 21 |
Renin inhibitor AGN-PC-09M9MJ family | 2 | 23 |
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... | 8 | 2 |
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family | 5 | 33 |
Cellular tumor antigen p53 and Microtubule-associated protein ... | 1 | 4 |
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... | 3 | 3 |
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... | 2 | 9 |
Cellular tumor antigen p53 inhibitor CHEMBL1395699 family | 1 | 30 |
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family | 2 | 11 |
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... | 1 | 16 |
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... | 2 | 2 |
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... | 4 | 11 |
Protein kinase C alpha type and Protein kinase C delta type in... | 4 | 37 |
Histamine H3 receptor ligand SureCN2784306 family | 5 | 3 |
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... | 2 | 0 |
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... | 3 | 21 |
Acetylcholinesterase inhibitor CHEMBL1651140 family | 4 | 4 |
Coagulation factor X and Prothrombin inhibitor AGN-PC-0759SH f... | 5 | 4 |
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... | 17 | 4 |
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... | 9 | 7 |
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... | 2 | 2 |
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-0759OR family | 4 | 7 |
Prostaglandin D2 receptor 2 ligand SureCN2189431 family | 7 | 1 |
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... | 2 | 5 |
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... | 3 | 2 |
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... | 2 | 19 |
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... | 1 | 16 |
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... | 5 | 12 |
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... | 3 | 0 |
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... | 15 | 2 |
Cysteinyl leukotriene receptor 1 and Peripheral myelin protein... | 1 | 1 |
Histone deacetylase 1 and Potassium voltage-gated channel subf... | 1 | 0 |
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... | 16 | 19 |
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... | 4 | 4 |
Prostaglandin D2 receptor and Prostaglandin E2 receptor EP2 su... | 2 | 0 |
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... | 5 | 2 |
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... | 2 | 2 |
NS5B protein inhibitor AC1O5AET family | 3 | 1 |
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... | 9 | 10 |
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... | 8 | 4 |
D(3) dopamine receptor ligand AGN-PC-075Z0O family | 2 | 3 |
Vascular endothelial growth factor receptor 2 and Vascular end... | 2 | 52 |
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... | 3 | 2 |
Cholinesterase and Acetylcholinesterase inhibitor 4-oxo-N-[9-(... | 11 | 13 |
Platelet-derived growth factor receptor beta and Macrophage co... | 1 | 4 |
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... | 2 | 3 |
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... | 3 | 4 |
Cytosolic phospholipase A2 inhibitor AGN-PC-00BH8R family | 6 | 13 |
Disintegrin and metalloproteinase domain-containing protein 17... | 13 | 3 |
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... | 11 | 12 |
Melanin-concentrating hormone receptor 1 and Melanin-concentra... | 12 | 0 |
Disintegrin and metalloproteinase domain-containing protein 17... | 16 | 2 |
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... | 42 | 20 |
Sonic hedgehog protein inhibitor 3-methoxy-1-methyl-4-oxo-5-ph... | 5 | 3 |
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... | 3 | 2 |
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... | 6 | 159 |
Cathepsin K inhibitor (1R,2R)-N-(1-cyanocyclopropyl)-2-(6-meth... | 3 | 0 |
Fatty-acid amide hydrolase 1 inhibitor [3-(3-carbamoylpyrrol-1... | 4 | 6 |
Substance-P receptor ligand AGN-PC-01VLKE family | 9 | 11 |
Angiopoietin-1 receptor and Vascular endothelial growth factor... | 7 | 2 |
Cannabinoid receptor 1 ligand AGN-PC-0766FR family | 4 | 3 |
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... | 1 | 1 |
Prostaglandin E synthase inhibitor 3-[4-(3-cyanopropoxy)-3-met... | 2 | 4 |
Beta-2 adrenergic receptor ligand SureCN4598646 family | 7 | 7 |
Translocator protein inhibitor AGN-PC-07BUUF family | 11 | 2 |
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... | 1 | 3 |
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... | 7 | 11 |
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... | 5 | 14 |
Disintegrin and metalloproteinase domain-containing protein 17... | 5 | 4 |
C-C chemokine receptor type 5 ligand N-methyl-4-[6-methyl-5-[[... | 2 | 2 |
Egl nine homolog 1 inhibitor 2-(2-methoxy-4-phenylphenyl)-8-[(... | 1 | 0 |
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... | 2 | 2 |
Platelet-activating factor receptor ligand N,N-dimethyl-6-phen... | 12 | 18 |
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... | 4 | 20 |
Mu-type opioid receptor ligand MITRAGYNINE family | 2 | 8 |
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... | 4 | 0 |
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... | 6 | 8 |
Coagulation factor X and Prothrombin inhibitor SureCN6434488 f... | 3 | 13 |
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... | 2 | 2 |
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... | 3 | 2 |
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... | 2 | 4 |
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... | 1 | 8 |
Vasopressin V2 receptor ligand SureCN4400636 family | 1 | 0 |
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... | 1 | 1 |
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... | 1 | 1 |
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... | 2 | 10 |
Melatonin receptor type 1B and Melatonin receptor type 1A liga... | 3 | 9 |
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... | 2 | 0 |
Substance-P receptor ligand AGN-PC-0D60L0 family | 2 | 7 |
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... | 12 | 7 |
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... | 6 | 2 |
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... | 23 | 5 |
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... | 1 | 0 |
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... | 5 | 0 |
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... | 2 | 6 |
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... | 1 | 12 |
Histamine H3 receptor ligand SureCN1397929 family | 1 | 1 |
5-hydroxytryptamine receptor 4 ligand 4-amino-5-chloro-N-[1-[8... | 2 | 2 |
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... | 58 | 15 |
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... | 6 | 0 |
Protein kinase C theta type and Protein kinase C delta type in... | 13 | 0 |
Melatonin receptor type 1A and Melatonin receptor type 1B liga... | 2 | 3 |
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... | 1 | 0 |
Prothrombin inhibitor AGN-PC-074I2Z family | 2 | 1 |
Signal transducer and activator of transcription 1-alpha/beta ... | 1 | 36 |
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... | 2 | 1 |
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... | 1 | 0 |
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... | 2 | 10 |
Potassium voltage-gated channel subfamily A member 5 ligand AG... | 1 | 0 |
Mitogen-activated protein kinase 14 inhibitor Aminopyridine N-... | 3 | 1 |
Thromboxane-A synthase and Platelet-activating factor receptor... | 1 | 6 |
Bile acid receptor ligand SureCN1243717 family | 1 | 4 |
Aurora kinase A inhibitor SureCN3802792 family | 2 | 3 |
DNA polymerase beta and Microtubule-associated protein tau inh... | 1 | 1 |
Platelet-derived growth factor receptor beta and Vascular endo... | 1 | 3 |
ATP-binding cassette sub-family G member 2 inhibitor 5-[(4-bro... | 1 | 1 |
Oxysterols receptor LXR-beta ligand indole derivative, 39 family | 2 | 0 |
Statistics of CFAM Database |
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes. |
How to cite our database |
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
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Last update by |
2014.08.29
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