CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6212
Family Name D(4) dopamine receptor and D(3) dopamine receptor ligand 3-benzyl-8-methoxy-2,4-dihydro-1H-chromeno[3,4-c]pyridin-5-one family
No. of Seeds 5 No. of Other Members 334
Family Centroid CFAMM00348195 Functional Category Bioactive with Natural Product
Superfamily D(4) dopamine receptor and D(3) dopamine receptor Binder Superfamily 3
Class Class 2426

Cousin Family NamesSeedsMembers
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
Cyclin-dependent kinase 2 Inhibitor Flavopiridol Family 4 124
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Acolbifene family 10 115
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Kappa-type opioid receptor Ligand Fedotozine Family 1 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Leukotriene B4 receptor 1 Ligand SC-51146 Family 6 315
DNA-dependent protein kinase catalytic subunit Inhibitor 4-mor... 7 54
DNA-dependent protein kinase catalytic subunit Inhibitor 7-pro... 5 49
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Acetylcholinesterase Inhibitor AP-2238 Family 2 109
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Androgen receptor Ligand 2-methoxy-4-(o-tolyloxy)benzonitrile ... 5 12
Amine oxidase [flavin-containing] B Inhibitor N-isobutyl-2-oxo... 4 8
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Acetylcholinesterase Inhibitor Taspine Family 1 0
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Cytochrome P450 2D6 Inhibitor 4-methylaminomethyl-7-methoxycou... 3 80
Acetylcholinesterase Inhibitor 6-methyl-4-(4-phenylpiperazin-1... 6 622
Androgen receptor Ligand Palodesangren E Family 12 43
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 27
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 10 6
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 3 27
Androgen receptor ligand (6R,7R)-6,7-diethyl-4-(trifluoromethy... 15 20
Neuropeptide S receptor and Prelamin-A/C ligand CHEMBL1352632 ... 1 25
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 4
Mu-type opioid receptor ligand 3-[(3R,4R)-1-[(2,4-dimethoxyphe... 2 4
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 117
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 0
Substance-P receptor ligand 3-[bis(4-fluorophenyl)methyl]-1-[(... 5 2
Acetylcholinesterase and Cholinesterase inhibitor [3-[4-(3,4-d... 3 18
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 191
Muscarinic acetylcholine receptor M5 and Muscarinic acetylchol... 1 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-[(4... 3 53
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 3 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 2
Acetylcholinesterase and Butyrylcholinesterase inhibitor [3-[[... 1 65
D(4) dopamine receptor ligand 8-methoxy-3-[(4-nitrophenyl)meth... 1 1
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 20
C-C chemokine receptor type 4 ligand AGN-PC-07AKPI family 1 5
DNA-(apurinic or apyrimidinic site) lyase and Inositol monopho... 1 22
Breast cancer type 1 susceptibility protein and Huntingtin inh... 1 7
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 2 110
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 7
Endothelin B receptor and Endothelin-1 receptor ligand AGN-PC-... 3 1
Amine oxidase [flavin-containing] B inhibitor (2S)-1-[[7-[(3-f... 2 15
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00370827 CHEMBL91938 Bioactive 8-methoxy-3-[[4-(trifluoromethyl)phenyl]methyl]-2,4-dihydro-1H-chromeno[3,4-c]pyridin-5-one
CFAMM00370665 CHEMBL329126 Bioactive 8-methoxy-3-[(4-methylphenyl)methyl]-2,4-dihydro-1H-chromeno[3,4-c]pyridin-5-one
CFAMM00370779 CHEMBL440506 Bioactive 8-methoxy-3-(2-phenylethyl)-2,4-dihydro-1H-chromeno[3,4-c]pyridin-5-one
CFAMM00370765 CHEMBL91273 Bioactive 3-[(4-fluorophenyl)methyl]-8-methoxy-2,4-dihydro-1H-chromeno[3,4-c]pyridin-5-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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