CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6259
Family Name Neuropeptide Y receptor type 1 ligand 1-[3-[1-(cyclohexylmethyl)piperidin-4-yl]propyl]-2-(phenoxymethyl)-4-(3-piperidin-1-ylpropoxy)benzimidazole family
No. of Seeds 15 No. of Other Members 9
Family Centroid CFAMM00371191 Functional Category Bioactive
Superfamily Neuropeptide Y receptor type 1 and Glutamate receptor ionotropic, NMDA 1 Binder Superfamily
Class Class 1268

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 3 23
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Oestrogen receptor and Estrogen receptor beta Ligand 4-(2-phen... 2 9
Platelet-derived growth factor receptor beta and Ephrin type-B... 9 16
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Platelet-derived growth factor receptor alpha and Platelet-der... 3 18
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 7 16
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Extracellular calcium-sensing receptor ligand SureCN2503512 fa... 3 17
Extracellular calcium-sensing receptor ligand SureCN2503519 fa... 1 0
Extracellular calcium-sensing receptor ligand SureCN2972008 fa... 4 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
B2 bradykinin receptor ligand (E)-3-[6-(2-oxopyrrolidin-1-yl)p... 3 2
Survival motor neuron protein inhibitor CHEMBL1379159 family 1 10
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 3
Neuropeptide Y receptor type 1 ligand 2-[(4-chlorophenoxy)meth... 5 13
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Melanin-concentrating hormone receptor 1 ligand SureCN3334861 ... 1 3
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 3 1
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 16 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 5 8
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 7 1
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 1-... 8 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Angiopoietin-1 receptor and Vascular endothelial growth factor... 2 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Histamine H1 receptor and Substance-P receptor ligand SureCN13... 24 48
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
D(2) dopamine receptor ligand SureCN11039666 family 1 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Transient receptor potential cation channel subfamily V member... 18 1
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1
5-hydroxytryptamine receptor 1A and Gonadotropin-releasing hor... 3 0
Metabotropic glutamate receptor 2 ligand 2-[[(1R,5S)-6-[(2,5-d... 2 3
5-hydroxytryptamine receptor 1A ligand AGN-PC-04UH85 family 2 3
Nociceptin receptor and Delta-type opioid receptor ligand 2-[3... 2 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 2
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8919280 f... 23 18
Acyl-CoA:cholesterol acyltransferase inhibitor AGN-PC-00FHC0 f... 2 0
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2-(dimethyla... 2 1
Coagulation factor X inhibitor AGN-PC-07C2VY family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00371181 CHEMBL158392 Bioactive 2-(phenoxymethyl)-4-(3-piperidin-1-ylpropoxy)-1-[3-(1-propan-2-ylpiperidin-4-yl)propyl]benzimidazole
CFAMM00371187 CHEMBL349328 Bioactive 1-[3-[1-[2-(4-iodophenyl)ethyl]piperidin-4-yl]propyl]-2-(phenoxymethyl)-4-(3-piperidin-1-ylpropoxy)benzimidazole
CFAMM00371200 CHEMBL439643 Bioactive 4-[4-[3-[2-(phenoxymethyl)-4-(3-piperidin-1-ylpropoxy)benzimidazol-1-yl]propyl]piperidin-1-yl]-1-phenylbutan-1-one
CFAMM00371186 CHEMBL155802 Bioactive 2-(phenoxymethyl)-4-(3-piperidin-1-ylpropoxy)-1-[3-[1-(3-piperidin-1-ylpropyl)piperidin-4-yl]propyl]benzimidazole
CFAMM00371179 CHEMBL434467 Bioactive 1-[3-(1-but-3-enylpiperidin-4-yl)propyl]-2-(phenoxymethyl)-4-(3-piperidin-1-ylpropoxy)benzimidazole
CFAMM00371192 CHEMBL345581 Bioactive 2-(phenoxymethyl)-1-[3-[1-(2-phenylethyl)piperidin-4-yl]propyl]-4-(3-piperidin-1-ylpropoxy)benzimidazole
CFAMM00371185 CHEMBL159220 Bioactive 1-[3-[1-(2-methylpropyl)piperidin-4-yl]propyl]-2-(phenoxymethyl)-4-(3-piperidin-1-ylpropoxy)benzimidazole
CFAMM00371198 CHEMBL155925 Bioactive 1-[3-(1-methylpiperidin-4-yl)propyl]-2-(phenoxymethyl)-4-(3-piperidin-1-ylpropoxy)benzimidazole
CFAMM00371191 CHEMBL348119 Bioactive 1-[3-[1-(cyclohexylmethyl)piperidin-4-yl]propyl]-2-(phenoxymethyl)-4-(3-piperidin-1-ylpropoxy)benzimidazole
CFAMM00371197 CHEMBL346243 Bioactive 2-(phenoxymethyl)-1-[3-[1-[(Z)-3-phenylprop-2-enyl]piperidin-4-yl]propyl]-4-(3-piperidin-1-ylpropoxy)benzimidazole
CFAMM00371190 CHEMBL156076 Bioactive 1-[3-[1-(2-cyclohexylethyl)piperidin-4-yl]propyl]-2-(phenoxymethyl)-4-(3-piperidin-1-ylpropoxy)benzimidazole
CFAMM00371183 CHEMBL347807 Bioactive 3-[4-[3-[2-(phenoxymethyl)-4-(3-piperidin-1-ylpropoxy)benzimidazol-1-yl]propyl]piperidin-1-yl]-1-phenylpropan-1-one
CFAMM00371196 CHEMBL346242 Bioactive 2-(phenoxymethyl)-1-[3-[1-(3-phenylpropyl)piperidin-4-yl]propyl]-4-(3-piperidin-1-ylpropoxy)benzimidazole
CFAMM00371182 CHEMBL347804 Bioactive 2-(phenoxymethyl)-4-(3-piperidin-1-ylpropoxy)-1-[3-(1-prop-2-enylpiperidin-4-yl)propyl]benzimidazole
CFAMM00371188 CHEMBL348123 Bioactive 1-[3-[1-(3-methylbutyl)piperidin-4-yl]propyl]-2-(phenoxymethyl)-4-(3-piperidin-1-ylpropoxy)benzimidazole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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