CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6275
Family Name 72 kDa type IV collagenase and Matrix metalloproteinase-9 inhibitor (2R)-N-hydroxy-3-(1H-indol-3-yl)-2-[(4-phenylphenyl)sulfonylamino]propanamide family
No. of Seeds 2 No. of Other Members 4
Family Centroid CFAMM00371344 Functional Category Bioactive
Superfamily Prelamin-A/C and Cyclin-dependent kinase 2 Binder Superfamily 2
Class Class 8

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Prothrombin Inhibitor Ximelegatran Family 8 157
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Substance-P receptor Ligand GSK424887 Family 8 184
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
CBP-501 family 7 8
E7820 family 9 56
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Thromboxane-A synthase Inhibitor CGS-22652 Family 37 95
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... 4 19
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
5-hydroxytryptamine receptor 2C Ligand Cyclo[(6-bromotryptopha... 3 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Prostaglandin G/H synthase 2 Inhibitor 2-(4-(methylsulfonyl)ph... 7 33
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Histone deacetylase Inhibitor ST-5732 Family 8 6
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Thromboxane A2 receptor and Thromboxane-A synthase ligand AGN-... 4 19
C-C chemokine receptor type 5 ligand AC1LAJEM family 4 14
Protein kinase C theta type and Protein kinase C delta type in... 7 17
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Histone deacetylase 3 and Histone deacetylase 6 inhibitor Tria... 20 37
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Cathepsin L1 inhibitor Bio2_000267 family 9 1
Neutrophil collagenase and Stromelysin-3 inhibitor AC1MORIH fa... 7 9
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 1 0
Neuropeptide Y receptor type 5 ligand 2-[4-(benzenesulfonamido... 2 27
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 4 0
Coagulation factor X inhibitor 6-chloro-N-[(3S)-1-[4-[2-[(dime... 5 8
Coagulation factor X and Trypsin-1 inhibitor 2-(5-carbamimidoy... 5 2
Disintegrin and metalloproteinase domain-containing protein 17... 5 9
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 3
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... 2 5
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-075TBZ family 2 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 3
Coagulation factor X and Trypsin-1 inhibitor 1-(3-carbamimidoy... 4 1
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Mineralocorticoid receptor and Glucocorticoid receptor ligand ... 5 0
Coagulation factor X inhibitor SureCN4172349 family 7 3
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 5 1
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 12 0
B1 bradykinin receptor ligand 2-[(2R)-7-chloro-1-naphthalen-2-... 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-N-... 3 2
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Pol polyprotein inhibitor AC1LAHQ9 family 8 15
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 3
Pancreatic alpha-amylase and Gastrin/cholecystokinin type B re... 7 1
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 7 1
Coagulation factor X inhibitor 6-chloro-N-[1-(2-fluoro-4-pyrid... 6 7
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 4
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 3
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 1
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 1 1
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 18
Proteinase-activated receptor 1 and Prothrombin ligand (2S)-N-... 3 23
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
Neprilysin and Endothelin-converting enzyme 1 inhibitor (2S)-2... 5 0
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 6 4
Stromelysin-3 and Neutrophil collagenase inhibitor AGN-PC-074N... 3 1
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor 2-(2,6... 3 10
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 3 1
5-hydroxytryptamine receptor 7 ligand 6-[(2R)-2-[2-(4-methylpi... 1 0
Coagulation factor X and Anionic trypsin inhibitor Sulfonamido... 2 4
5-hydroxytryptamine receptor 6 ligand 3,4-dichloro-N-[3-[[(2R)... 5 0
Coagulation factor X and Trypsin-1 inhibitor SureCN6166035 family 1 2
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 5 2
KiSS-1 receptor ligand SureCN5132924 family 2 4
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
KiSS-1 receptor ligand N-[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-... 1 0
Somatostatin receptor type 4 and Somatostatin receptor type 5 ... 3 4
Suppressor of tumorigenicity 14 protein and Prothrombin inhibi... 1 3
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Prostaglandin G/H synthase 2 inhibitor SureCN6345015 family 6 1
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
5-hydroxytryptamine receptor 6 ligand 2-[[(1Z)-1-[5-(benzenesu... 1 0
5-hydroxytryptamine receptor 6 ligand 4-bromo-N-[3-[[(2S)-1-me... 4 0
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor [2-(me... 1 0
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-075O... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00371344 CHEMBL155923 Bioactive (2R)-N-hydroxy-3-(1H-indol-3-yl)-2-[(4-phenylphenyl)sulfonylamino]propanamide
CFAMM00371343 CHEMBL559194 Bioactive (2R)-N-[[(3S)-1-carbamimidoylpiperidin-3-yl]methyl]-3-(1H-indol-3-yl)-2-(naphthalen-2-ylsulfonylamino)propanamide;hydrochloride

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45918 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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