CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM629
Family Name Neutrophil elastase inhibitor phenyl N-[(2S)-1-[(2S)-2-[[(3S)-6-amino-5,5-difluoro-2-methyl-4-oxohexan-3-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate family
No. of Seeds 10 No. of Other Members 4
Family Centroid CFAMM00313892 Functional Category Bioactive
Superfamily Neutrophil elastase Binder Superfamily
Class Class 589

Cousin Family NamesSeedsMembers
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Flovagatran family 12 546
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Cathepsin B and Cathepsin S Inhibitor Cbz-ile-leu-ala-leuvsme ... 12 14
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Cathepsin K inhibitor (4-phenylphenyl) (3S)-3-[[(3S)-1,2-dioxo... 4 10
Prothrombin and Tissue-type plasminogen activator inhibitor CH... 10 5
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Neutrophil elastase inhibitor benzyl N-[(2S)-1-[(2S)-2-[[(3S)-... 4 0
Neutrophil elastase inhibitor benzyl N-[(2S)-3-methyl-1-[(2S)-... 2 0
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Neutrophil elastase inhibitor 4-[(E)-3-[[(2S)-3-methyl-1-oxo-1... 2 6
Dipeptidyl peptidase 4 inhibitor 3-[[2-[(2S,4S)-2-cyano-4-fluo... 5 1
Beta-lactamase and Histone-lysine N-methyltransferase 2A inhib... 1 7
Voltage-dependent N-type calcium channel subunit alpha-1B liga... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00313896 CHEMBL108504 Bioactive phenyl N-[(2S)-1-[(2S)-2-[[(3S)-6-(benzylamino)-5,5-difluoro-2-methyl-4-oxohexan-3-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
CFAMM00313889 CHEMBL2372974 Bioactive (4-fluorophenyl) N-[(2S)-3-methyl-1-oxo-1-[(2S)-2-[[(3S)-1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl]carbamoyl]pyrrolidin-1-yl]butan-2-yl]carbamate
CFAMM00313895 CHEMBL417935 Bioactive phenyl N-[(2S)-3-methyl-1-oxo-1-[(2S)-2-[[(3S)-1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl]carbamoyl]pyrrolidin-1-yl]butan-2-yl]carbamate
CFAMM00313888 CHEMBL306202 Bioactive tert-butyl N-[(4S)-2,2-difluoro-5-methyl-4-[[(2S)-1-[(2S)-3-methyl-2-(phenoxycarbonylamino)butanoyl]pyrrolidine-2-carbonyl]amino]-3-oxohexyl]carbamate
CFAMM00313887 CHEMBL305259 Bioactive phenyl N-[(2S)-1-[(2S)-2-[[(3S)-6-(benzylamino)-5,5-difluoro-2-methyl-4-oxohexan-3-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate;2,2,2-trifluoroacetic acid
CFAMM00313893 CHEMBL304114 Bioactive phenyl N-[(2S)-1-[(2S)-2-[[(3S)-5,5-difluoro-2-methyl-6-(methylamino)-4,6-dioxohexan-3-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
CFAMM00313892 CHEMBL110125 Bioactive phenyl N-[(2S)-1-[(2S)-2-[[(3S)-6-amino-5,5-difluoro-2-methyl-4-oxohexan-3-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
CFAMM00313885 CHEMBL66128 Bioactive phenyl N-[(2S)-1-[(2S)-2-[[(3S)-6-amino-5,5-difluoro-2-methyl-4-oxohexan-3-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate;2,2,2-trifluoroacetic acid
CFAMM00313891 CHEMBL108477 Bioactive phenyl N-[(2S)-1-[(2S)-2-[[(3S)-6-(butoxycarbonylamino)-5,5-difluoro-2-methyl-4-oxohexan-3-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
CFAMM00313897 CHEMBL110174 Bioactive phenyl N-[(2S)-1-[(2S)-2-[[(3S)-6-acetamido-5,5-difluoro-2-methyl-4-oxohexan-3-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48711 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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