CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6300
Family Name cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-specific 3',5'-cyclic phosphodiesterase 4C inhibitor methyl 3-[3-(cyclopentylmethyl)-2,4-dioxopyrido[2,3-d]pyrimidin-1-yl]benzoate family
No. of Seeds 3 No. of Other Members 22
Family Centroid CFAMM00371475 Functional Category Bioactive
Superfamily Calcium-dependent chloride channel-1 Ligand MSI-1956 Superfamily
Class Class 1588

Cousin Family NamesSeedsMembers
Prostaglandin G/H synthase 2 Inhibitor Niflumic Acid Family 7 119
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 9 6
B1 bradykinin receptor ligand AGN-PC-00CTAF family 1 3
B1 bradykinin receptor ligand methyl 2-fluoro-6-[3-fluoro-4-[[... 22 11
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
B1 bradykinin receptor ligand methyl 2-[4-[(1R)-1-[[3-[(2-cyan... 8 7
Neutrophil elastase inhibitor AGN-PC-076VCN family 3 25
Histone deacetylase 1 inhibitor SureCN4538615 family 2 2
Cyclic AMP-dependent transcription factor ATF-1 and Nuclear fa... 3 0
P2Y purinoceptor 12 inhibitor SureCN3928692 family 5 0
P2Y purinoceptor 12 inhibitor SureCN3923520 family 5 0


External ID

Functional Category

Molecule Name

CFAMM00371476 CHEMBL345917 Bioactive methyl 3-[3-(3-bicyclo[2.2.1]heptanylmethyl)-2,4-dioxopyrido[2,3-d]pyrimidin-1-yl]benzoate
CFAMM00371475 CHEMBL351567 Bioactive methyl 3-[3-(cyclopentylmethyl)-2,4-dioxopyrido[2,3-d]pyrimidin-1-yl]benzoate
CFAMM00371498 CHEMBL156140 Bioactive SureCN2932520

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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