CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6332
Family Name Peptide deformylase inhibitor (2R)-N-[(2S)-3,3-dimethyl-1-oxo-1-pyridin-2-ylbutan-2-yl]-2-[[formyl(hydroxy)amino]methyl]hexanamide family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00371741 Functional Category Bioactive with Natural Product
Superfamily Amine oxidase [flavin-containing] A and Dual specificity mitogen-activated protein kinase kinase 1 Binder Superfamily
Class Class 1390

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Indinavir Family 36 211
HIV protease Inhibitor Saquinavir Family 64 428
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
HIV-1 protease Inhibitor Atazanavir Family 16 58
26S proteasome Inhibitor Bortezomib Family 7 65
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Histone deacetylase 1 Inhibitor MS-275 Family 4 41
Neuromedin-K receptor Ligand SB222200 Family 17 235
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Coagulation factor X Inhibitor Otamixaban Family 9 21
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
Histone deacetylase 1 Inhibitor Pyroxamide Family 4 13
CP-18770 family 6 27
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Amine oxidase [flavin-containing] B Inhibitor Lazebemide Family 2 13
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
5-hydroxytryptamine receptor 2C Ligand Cyclo[(6-bromotryptopha... 3 17
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 1 Ligand N-(2-phenylpropyl)qui... 3 1
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-5-[[(2S)-2-[... 3 0
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 2 7
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 17 14
Cholecystokinin receptor type A ligand A-65186 family 2 6
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 2 11
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
Neuronal acetylcholine receptor subunit alpha-7 and Acetylchol... 2 3
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Disintegrin and metalloproteinase domain-containing protein 17... 3 3
C-C chemokine receptor type 1 ligand N-[(2S,3S,5R)-5-carbamoyl... 10 4
Translocator protein inhibitor AGN-PC-08WI0V family 1 0
Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3
Substance-K receptor ligand N-[1-[[(2S)-1-[[1-(oxan-4-ylmethyl... 3 0
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
Histamine H3 receptor ligand SureCN1857507 family 1 4
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Cathepsin L1 and Cathepsin S inhibitor N-[(2S)-4-methyl-1-oxo-... 3 3
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Melanin-concentrating hormone receptor 1 ligand N-[(3S)-1-[[(3... 2 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(meth... 1 1
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand N-(oxan-... 2 0
Seprase and Prolyl endopeptidase inhibitor [(2R)-1-[(2R)-2-[(2... 4 2
Neutrophil elastase inhibitor N-[(2S)-3-methyl-1-oxo-1-[(2S)-2... 4 4
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Seprase and Prolyl endopeptidase inhibitor 7-chloro-N-[2-[(2S)... 3 3
Metabotropic glutamate receptor 5 ligand AGN-PC-09SALK family 2 15
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2S,4R)... 2 2
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Platelet-activating factor receptor ligand N,N-diethyl-3-[(4R)... 11 0
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
KiSS-1 receptor ligand SureCN5132924 family 2 4
72 kDa type IV collagenase and Interstitial collagenase inhibi... 1 1
Dipeptidyl peptidase 4 inhibitor SureCN5777667 family 1 4
Interstitial collagenase and Stromelysin-1 inhibitor CHEMBL887... 1 0
Histone deacetylase 6 and Histone deacetylase 8 inhibitor N-hy... 1 0
N-[(1S,5R)-2-formyl-6,6-dimethyl-3-bicyclo[3.1.0]hex-2-enyl]py... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00371741 CHEMBL156427 Bioactive (2R)-N-[(2S)-3,3-dimethyl-1-oxo-1-pyridin-2-ylbutan-2-yl]-2-[[formyl(hydroxy)amino]methyl]hexanamide
CFAMM00371743 CHEMBL1643873 Bioactive N-[(3S,5R)-5-[[formyl(hydroxy)amino]methyl]-2-methyl-4-oxononan-3-yl]isoquinoline-1-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26190 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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