CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6340
Family Name Neuronal acetylcholine receptor subunit alpha-4 and Neuronal acetylcholine receptor subunit beta-2 ligand AGN-PC-0A3D3B family
No. of Seeds 11 No. of Other Members 4
Family Centroid CFAMM00371818 Functional Category Bioactive
Superfamily Neuronal acetylcholine receptor subunit alpha-4 and Cytochrome P450 1A2 Binder Superfamily
Class Class 1004

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Acetylcholinesterase Inhibitor Pyridostigmine Family 5 197
Histamine H1 receptor Ligand Doxylamine Family 2 91
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... 49 172
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
PF-02545920 family 16 140
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
Dihydroorotate dehydrogenase Inhibitor LY214352 Family 2 17
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 3 24
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Neuronal acetylcholine receptor subunit beta-2 Ligand ABT-594 ... 4 5
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Translocator protein inhibitor SureCN13502542 family 20 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Neuronal acetylcholine receptor subunit alpha-3 and Neuronal a... 2 0
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 6 4
Neuropeptide Y receptor type 1 ligand SureCN7959923 family 1 6
5-hydroxytryptamine receptor 2A and Alpha-1A adrenergic recept... 4 1
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 7
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Prostaglandin D2 receptor 2 ligand 2-[3-(4-chlorophenoxy)-5-fl... 3 3
Lysosomal Pro-X carboxypeptidase inhibitor 1-(4-chloropyridin-... 6 1
RAC-alpha serine/threonine-protein kinase inhibitor N-[(2S)-1-... 2 1
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Sodium-dependent serotonin transporter and Sodium-dependent do... 2 0
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 6 1
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Neuronal acetylcholine receptor subunit alpha-7 ligand 5-[6-[[... 1 0
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 7
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 8
Renin inhibitor SureCN6042213 family 2 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 0
Metabotropic glutamate receptor 5 and Cytochrome P450 1A2 liga... 1 1
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 5
Protein kinase C theta type and Protein kinase C delta type in... 10 7
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 2
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
B2 bradykinin receptor ligand SureCN13145573 family 7 6
Neuronal acetylcholine receptor subunit alpha-3 and Neuronal a... 4 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 6 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 1
Glutamate receptor ionotropic, NMDA 2B and Cytochrome P450 2D6... 2 3
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-073... 1 1
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00371821 CHEMBL97505 Bioactive AGN-PC-00GLY4
CFAMM00371820 CHEMBL99714 Bioactive 2-chloro-5-[(1-methylpyrrolidin-2-yl)methoxy]-3-[(E)-2-pyridin-4-ylethenyl]pyridine
CFAMM00371813 CHEMBL79737 Bioactive 2-chloro-3-pyridin-3-yl-5-[[(2S)-pyrrolidin-2-yl]methoxy]pyridine
CFAMM00371826 CHEMBL95584 Bioactive 2-chloro-5-[(1-methylpyrrolidin-2-yl)methoxy]-3-[(E)-2-pyridin-3-ylethenyl]pyridine
CFAMM00371819 CHEMBL83986 Bioactive 2-chloro-3-(6-fluoropyridin-3-yl)-5-[[(2S)-pyrrolidin-2-yl]methoxy]pyridine
CFAMM00371825 CHEMBL156452 Bioactive SureCN6585515
CFAMM00371818 CHEMBL95512 Bioactive AGN-PC-0A3D3B
CFAMM00371824 CHEMBL157188 Bioactive SureCN6582607
CFAMM00371817 CHEMBL552408 Bioactive 2-chloro-3-(2-fluoropyridin-4-yl)-5-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]pyridine
CFAMM00371823 CHEMBL562523 Bioactive 2-chloro-5-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-3-[(E)-2-pyridin-4-ylethenyl]pyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27425 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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