CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6341
Family Name Platelet-activating factor receptor ligand YM-461 family
No. of Seeds 1 No. of Other Members 11
Family Centroid CFAMM00371834 Functional Category Bioactive with Natural Product
Superfamily Platelet-activating factor receptor and Histamine H3 receptor Binder Superfamily
Class Class 1491

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Histamine H1 receptor Ligand Triprolidine Family 19 316
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Amg 423 family 7 47
ABC294640 family 5 75
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Aromatase Inhibitor Rogletimide Family 1 2
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Alpha-1A adrenergic receptor Ligand L-771688 Family 8 14
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Cycl... 7 6
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Pol polyprotein inhibitor penicillin deriv. 40 family 2 4
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 1 0
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor S-(3-pyri... 1 6
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor lig... 2 8
Cathepsin K inhibitor SureCN2155973 family 3 1
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 8
Prothrombin and Trypsin-1 inhibitor SureCN12636557 family 9 1
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
Dipeptidyl peptidase 4 inhibitor SureCN3389584 family 2 2
Prothrombin inhibitor AGN-PC-09QKE4 family 1 0
Neuronal acetylcholine receptor subunit alpha-7 ligand AGN-PC-... 7 1
Neuronal acetylcholine receptor subunit alpha-7 ligand 1-(4-me... 1 0
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... 5 8
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-pyridin-4-ylpip... 1 2
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 1 2
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Platelet-activating factor receptor ligand N,N-diethyl-3-[(4R)... 11 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Thromboxane-A synthase inhibitor ethyl 5-[(Z)-[pyridin-3-yl-[3... 5 0
Survival motor neuron protein and Microtubule-associated prote... 1 0
Voltage-dependent N-type calcium channel subunit alpha-1B liga... 5 0
Voltage-dependent N-type calcium channel subunit alpha-1B liga... 2 1
Neutrophil elastase and Chymotrypsin-like elastase family memb... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00371834 CHEMBL156461 Bioactive YM-461

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

25240 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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