CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6378
Family Name Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl-2,3,4a,5,6,7,8,8a-octahydroquinolin-1-yl]-(1H-indol-4-yl)methanone family
No. of Seeds 2 No. of Other Members 41
Family Centroid CFAMM00372471 Functional Category Bioactive with Natural Product
Superfamily Cannabinoid receptor 2 and 5-hydroxytryptamine receptor 4 Binder Superfamily
Class Class 4038

Cousin Family NamesSeedsMembers
Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
5-hydroxytryptamine receptor 3A Ligand Dolasetron Family 12 171
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Gastrin/cholecystokinin type B receptor ligand oligopeptide Ce... 35 209
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
DNA Binder Elliptinium Acetate Family 11 116
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Dihydroorotate dehydrogenase Inhibitor Brequinar Family 9 122
Retinoic acid receptor alpha Ligand LG100268 Family 2 33
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Growth hormone receptor Ligand EP-51216 Family 34 390
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Eluxadoline family 4 85
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Dihydroorotate dehydrogenase Inhibitor Cinchoninic Acid Family 1 21
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Tyrosine-protein phosphatase non-receptor type 1 Ligand 6-(oxa... 1 5
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Lethal factor Inhibitor 3-(2,5-dimethyl-1h-pyrrol-1-yl)benzoic... 2 44
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Fatty acid-binding protein, adipocyte Inhibitor 1-benzyl-2,3-d... 1 8
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Kinesin-like protein KIF11 Inhibitor Methyl 7-tert-butyl-9h-ca... 2 9
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Histone deacetylase Inhibitor ST-5732 Family 8 6
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
Substance-K receptor ligand 1-N,2-N-bis[2-(1H-indol-3-yl)ethyl... 1 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 6 0
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 2 22
Prostaglandin E2 receptor EP4 subtype and Prostaglandin D2 rec... 8 17
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Melanocortin receptor 4 and Potassium voltage-gated channel su... 2 12
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 3 28
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 5 0
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Sodium-dependent serotonin transporter and D(2) dopamine recep... 13 2
Vascular endothelial growth factor receptor 2 ligand indolyl q... 4 3
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
NS5B protein inhibitor AC1NQMYG family 6 12
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4R,... 3 7
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 2 11
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
Renin inhibitor SureCN1144364 family 3 15
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Retinoic acid receptor alpha and Retinoic acid receptor beta l... 1 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 4 53
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Glutamate receptor ionotropic, NMDA 1 ligand (3S)-3-[2-[4-(ami... 2 2
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Metabotropic glutamate receptor 1 ligand [11C]JNJ-16567083 family 9 2
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 2 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4S,... 5 2
Histone deacetylase inhibitor (3S,6S,9S,12R)-3-[(2S)-butan-2-y... 1 0
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Cytochrome P450 2D6 and Cytochrome P450 2C19 inhibitor Demethy... 1 4
Renin and Potassium voltage-gated channel subfamily H member 2... 13 11
NS5B protein inhibitor AC1NQMYP family 5 0
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Prostaglandin D2 receptor 2 ligand 2-[1-(4-benzamidobenzoyl)is... 4 9
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Coagulation factor VII and Tissue factor inhibitor AGN-PC-00R9... 2 10
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 1 1
RAC-beta serine/threonine-protein kinase inhibitor SureCN57283... 2 0
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Transient receptor potential cation channel subfamily V member... 1 5
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Beta-2 adrenergic receptor ligand SureCN5346426 family 8 0
Hydroxycarboxylic acid receptor 2 and Cytochrome P450 2C9 liga... 2 6
Beta-2 adrenergic receptor ligand SureCN4598646 family 7 7
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 18
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Cyclin-dependent kinase 2 and Vascular endothelial growth fact... 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Cannabinoid receptor 1 ligand (4-hydroxynaphthalen-1-yl)-[1-(2... 2 0
Stromelysin-3 and Neutrophil collagenase inhibitor AGN-PC-074N... 3 1
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Gonadotropin-releasing hormone receptor ligand methyl 4-[2-[[(... 2 1
KiSS-1 receptor ligand SureCN5132924 family 2 4
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
Gonadotropin-releasing hormone receptor ligand 4-[2-[[(2S)-2-[... 1 0
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
KiSS-1 receptor ligand N-[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-... 1 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 4 2
Beta-3 adrenergic receptor ligand SureCN5704018 family 4 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 5
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 2 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 2
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 16 3
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 4 4
Mitogen-activated protein kinase 14 inhibitor AGN-PC-08866Z fa... 2 0
Glutamate carboxypeptidase 2 inhibitor 1-[(3-carboxyphenyl)met... 4 11
Coagulation factor VII and Tissue factor inhibitor 5-azaindole... 4 3
Coagulation factor VII and Tissue factor inhibitor 5-azaindole... 1 0
Lutropin-choriogonadotropic hormone receptor ligand 5-[2-(4-te... 1 1
Vascular endothelial growth factor receptor 2 ligand SureCN520... 1 0
Calcium/calmodulin-dependent protein kinase type II subunit de... 1 0
Coagulation factor VII and Tissue factor inhibitor 5-azaindole... 1 0
Putative NP ZINC15919780 Family 2 0
2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-2-ium-8-carboxylate N... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00372440 CHEMBL1765261 Bioactive [(4S,4aR,8aS)-4-hydroxy-4-phenyl-2,3,4a,5,6,7,8,8a-octahydroquinolin-1-yl]-(1H-indol-5-yl)methanone
CFAMM00372471 CHEMBL1765246 Bioactive [(4R,4aS,8aR)-4-hydroxy-4-phenyl-2,3,4a,5,6,7,8,8a-octahydroquinolin-1-yl]-(1H-indol-4-yl)methanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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