CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6382
Family Name Growth hormone secretagogue receptor type 1 and Dihydrofolate reductase ligand AGN-PC-00HDDW family
No. of Seeds 3 No. of Other Members 6
Family Centroid CFAMM00372495 Functional Category Bioactive
Superfamily Growth hormone secretagogue receptor type 1 and cAMP Binder Superfamily
Class Class 857

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Neuropeptide Y receptor type 5 Ligand CGP71683A Family 5 74
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
SB989 family 17 91
Tryptase Inhibitor Babim Family 12 90
Corticotropin-releasing factor receptor 1 Ligand CRA1000 Family 4 39
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(4-e... 2 5
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family 27 48
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Protein farnesyltransferase subunit beta Inhibitor BMS-316810 ... 11 18
Corticotropin-releasing factor receptor 1 Ligand N-mesityl-6-m... 3 2
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 8
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 4
5-hydroxytryptamine receptor 6 ligand AGN-PC-03P3TZ family 6 88
5-hydroxytryptamine receptor 6 ligand AGN-PC-031XQS family 1 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Nociceptin receptor and Kappa-type opioid receptor ligand 1-[1... 4 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Thymidylate synthase inhibitor AGN-PC-003VKA family 1 1
Thymidylate synthase inhibitor AGN-PC-003VK7 family 1 4
Platelet-activating factor receptor ligand 6-(4-fluorophenyl)-... 1 3
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Cannabinoid receptor 2 ligand 2-tert-butyl-5-ethylsulfonyl-1-(... 28 32
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
Cyclin-dependent kinase 1 inhibitor 4-[[4-(3H-benzimidazol-5-y... 1 0
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0760... 4 0
Growth hormone secretagogue receptor type 1 ligand SureCN63605... 5 7
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 2-[4... 5 5
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 1
Neuropeptide Y receptor type 5 and Cytochrome P450 1A2 ligand ... 8 19
Neuropeptide Y receptor type 5 ligand 2-(3-phenylpiperidin-1-y... 6 2
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 3 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor AG... 3 1
Cannabinoid receptor 2 ligand 4-[[2-tert-butyl-1-(cyclohexylme... 2 0
Cannabinoid receptor 2 ligand 4-[2-tert-butyl-1-(oxan-4-ylmeth... 5 0
Prostaglandin G/H synthase 2 inhibitor 4-N,4-N-diethyl-2-(4-me... 5 1
Dihydrofolate reductase inhibitor WR 158122 family 1 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 1 0
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
5-hydroxytryptamine receptor 6 ligand 8-(1-pyrrolidin-3-ylpyrr... 1 0
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Nuclear receptor subfamily 1 group I member 2 ligand AGN-PC-07... 2 13
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 3
Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... 2 0
Focal adhesion kinase 1 and Protein-tyrosine kinase 2-beta inh... 1 1
Gonadotropin-releasing hormone receptor ligand AGN-PC-00AWCA f... 1 0
Carbonic anhydrase 2 and Carbonic anhydrase 9 inhibitor ZINC00... 1 0
5-hydroxytryptamine receptor 2B ligand SureCN1299053 family 1 1
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 1 0
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 2 9
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 1 3
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 3 3
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 1 0
D(2) dopamine receptor and D(4) dopamine receptor ligand 3-[1-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00372495 CHEMBL209443 Bioactive AGN-PC-00HDDW
CFAMM00372494 CHEMBL378909 Bioactive AGN-PC-00HD9L
CFAMM00372492 CHEMBL481367 Bioactive AGN-PC-0509MT

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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