CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6387
Family Name Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL1568192 family
No. of Seeds 1 No. of Other Members 5
Family Centroid CFAMM00372528 Functional Category Bioactive with Natural Product
Superfamily D(2) dopamine receptor and Prelamin-A/C Binder Superfamily
Class Class 2208

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
PF-02545920 family 16 140
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Sodium channel protein type 4 subunit alpha Ligand 3-(4-phenox... 2 4
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
D(2) dopamine receptor Ligand SLV-314 Family 19 69
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YUW... 2 9
Sigma non-opioid intracellular receptor 1 ligand 1'-butyl-6-me... 23 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 10
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 5
Smoothened homolog inhibitor AGN-PC-088VBV family 1 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 5 40
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 9 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Sigma non-opioid intracellular receptor 1 ligand 6-methoxy-1'-... 2 0
Muscarinic acetylcholine receptor M3 ligand 3-fluoro-2-(3-pipe... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
Serine/threonine-protein kinase B-raf inhibitor pyrrole-based ... 2 0
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand Piper... 3 14
Neuronal acetylcholine receptor subunit alpha-7 ligand 5-[6-[[... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 1
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
Prostaglandin D2 receptor 2 ligand 2-[4-(difluoromethoxy)-2-et... 1 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN4806204 f... 13 7
Serine/threonine-protein kinase Chk1 and Aurora kinase B inhib... 14 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 3 0
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 2 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Protein kinase C theta type and Protein kinase C delta type in... 10 7
B2 bradykinin receptor ligand SureCN13145573 family 7 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
RAC-alpha serine/threonine-protein kinase and Rho-associated p... 1 0
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... 2 0
Sodium channel protein type 4 subunit alpha ligand AGN-PC-006B... 3 2
Tyrosine-protein kinase ITK/TSK inhibitor N-[(3Z)-3-(6-methoxy... 2 4
Dual specificity mitogen-activated protein kinase kinase 1 inh... 8 7
Acetylcholinesterase and Cholinesterase inhibitor P10358 family 2 0
Thyroid hormone receptor beta and TGF-beta receptor type-1 lig... 1 1
Serine/threonine-protein kinase pim-3 and Serine/threonine-pro... 4 6


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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