CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6392
Family Name Prelamin-A/C and Lysine-specific demethylase 4E inhibitor 4-(4-acetylphenyl)-N-(4-chlorophenyl)piperazine-1-carboxamide family
No. of Seeds 2 No. of Other Members 3
Family Centroid CFAMM00372557 Functional Category Bioactive
Superfamily Vasopressin V2 receptor and Prelamin-A/C Binder Superfamily
Class Class 1375

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Motilin receptor Ligand GSK962040 Family 30 457
Pan-DAC Inhibitor AR-42 Family 21 153
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
C-C chemokine receptor type 5 Ligand Tak-220 Family 8 56
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Bifunctional epoxide hydrolase 2 Inhibitor N-(3-chloro-phenyl)... 2 43
Cannabinoid receptor 1 Ligand 1-(bis(4-chlorophenyl)methyl)-3-... 4 44
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 7 35
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Phospholipase D1 Inhibitor Halopemide Family 17 111
Metabotropic glutamate receptor 5 Ligand N-(3-acetamidophenyl)... 4 20
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
MO15-related protein kinase Pfmrk Inhibitor 2-chloro-n-(o-toly... 6 28
D(2) dopamine receptor Ligand PD-168077 Family 6 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Vasopressin V2 receptor and Vasopressin V1a receptor ligand N-... 5 8
Vasopressin V1a receptor and Vasopressin V2 receptor ligand CH... 3 5
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZBI0 family 2 16
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C8 inhib... 6 5
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 2 0
Rho-associated protein kinase 2 inhibitor N-(7-chloro-1-oxo-2H... 13 42
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEDE family 7 17
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZFJZ family 1 3
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 15 24
C-C chemokine receptor type 3 ligand 4-[(3-acetylphenyl)carbam... 3 4
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Coagulation factor X inhibitor 3-amino-4-chloro-N-[(1R)-2-[4-(... 1 1
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-5-amino-2-c... 3 4
C-C chemokine receptor type 3 ligand SureCN6703027 family 2 1
Vasopressin V2 receptor ligand [2-chloro-4-(prop-2-enylamino)p... 3 14
Hypoxia-inducible factor 1-alpha and Ubiquitin carboxyl-termin... 1 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 2 4
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 3
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Cellular tumor antigen p53 and Inositol monophosphatase 1 inhi... 1 12
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 24 11
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 6
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 8 1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 2 2
C-C chemokine receptor type 3 and Sodium-dependent serotonin t... 12 2
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
ALK tyrosine kinase receptor ligand 4-fluoro-N-[6-(piperidin-1... 10 7
Inosine-5'-monophosphate dehydrogenase inhibitor 2-chloro-5-[2... 3 0
C-C chemokine receptor type 3 ligand 1-(3-acetylphenyl)-3-[3-[... 9 1
P2X purinoceptor 7 inhibitor SureCN3652462 family 5 2
Coagulation factor X and Prothrombin inhibitor SureCN14502287 ... 16 5
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 3
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
Nociceptin receptor and Delta-type opioid receptor ligand spir... 25 9
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
Coagulation factor X inhibitor N-(4-chlorophenyl)-2-[[4-(2-oxo... 2 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[5-... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 0
Melanin-concentrating hormone receptor 1 ligand SureCN13451707... 3 1
C-C chemokine receptor type 3 ligand AGN-PC-075BAT family 1 0
Sodium-dependent noradrenaline transporter inhibitor AGN-PC-07... 1 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 4
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 4 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZK family 3 0
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
Vasopressin V2 receptor and Vasopressin V1a receptor ligand (2... 4 0
C-C chemokine receptor type 5 ligand AC1MHP8Y family 1 0
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 1 3
C-X-C chemokine receptor type 3 ligand AGN-PC-00PW0E family 3 11
C-C chemokine receptor type 2 ligand AGN-PC-00D2HV family 2 2
Acetylcholinesterase inhibitor 1-(1-benzyl-3,4-dihydro-2H-quin... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00372558 CHEMBL440969 Bioactive SureCN14490803
CFAMM00372557 CHEMBL547977 Bioactive 4-(4-acetylphenyl)-N-(4-chlorophenyl)piperazine-1-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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