CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6444
Family Name D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-[4-(4-chlorophenyl)piperazin-1-yl]butyl]-3-methoxybenzamide family
No. of Seeds 6 No. of Other Members 16
Family Centroid CFAMM00179467 Functional Category Bioactive
Superfamily D(4) dopamine receptor and D(3) dopamine receptor Binder Superfamily 2
Class Class 1458

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand phenylpiperazine derivative Arip... 3 53
D(2) dopamine receptor Ligand Nemonapride Family 70 283
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
5-hydroxytryptamine receptor 3A Ligand KB-6806 Family 12 11
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Tubulin Inhibitor WR85915 Family 3 15
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Sodium channel protein type 10 subunit alpha and Sodium channe... 2 13
Urotensin-2 receptor Ligand SB-436811 Family 6 71
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
Metabotropic glutamate receptor 5 Ligand N-(3-(3-cyanobenzamid... 2 13
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
D(4) dopamine receptor ligand AGN-PC-004XJQ family 2 1
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Stromelysin-1 and 72 kDa type IV collagenase inhibitor [(2S)-2... 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(4-... 3 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
D(3) dopamine receptor and D(1A) dopamine receptor ligand N-[(... 6 14
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 1
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 0
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
Prelamin-A/C and Cruzipain inhibitor CHEMBL1598118 family 1 3
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 2 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 3 6
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X1U ... 2 3
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
C-C chemokine receptor type 1 ligand SureCN3164653 family 2 1
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Melanocortin receptor 4 ligand 3-amino-N-[(2R)-3-(2,4-dichloro... 1 9
Microsomal triglyceride transfer protein large subunit inhibit... 3 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (2R... 8 9
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand CHEMB... 6 3
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 0
Receptor-type tyrosine-protein kinase FLT3 ligand (3Z)-5-chlor... 1 4
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-chloro-5-... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 8
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 10
Bifunctional epoxide hydrolase 2 and RAF proto-oncogene serine... 4 10
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 0
Poly [ADP-ribose] polymerase 1 inhibitor 6-[[4-(4-chlorophenyl... 1 0
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-fluoro-5-hydro... 2 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 5
Urotensin-2 receptor and Cytochrome P450 3A4 ligand 5-chloro-3... 2 1
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
D(3) dopamine receptor and D(4) dopamine receptor ligand SureC... 3 19
Cyclic AMP-specific phosphodiesterase SSPDE4A1A inhibitor AGN-... 2 8
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 4 4
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6627432 f... 6 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KJY family 5 4
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KFD family 1 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 28 30
Growth hormone secretagogue receptor type 1 ligand N-[4-[(2S)-... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 0
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 10
Metabotropic glutamate receptor 5 ligand N-(3-chlorophenyl)-2-... 2 3
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 1 1
D(2) dopamine receptor and D(3) dopamine receptor ligand 1-(3-... 2 0
Thioredoxin glutathione reductase and Microtubule-associated p... 1 2
Potassium voltage-gated channel subfamily H member 2 ligand me... 3 0
Sodium channel protein type 1 subunit alpha and Sodium channel... 3 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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