CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6484
Family Name Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-methylphenyl)methylamino]propylamino]-1H-quinolin-4-one family
No. of Seeds 9 No. of Other Members 32
Family Centroid CFAMM00373072 Functional Category Bioactive
Superfamily Methionine--tRNA ligase and Methionine--tRNA ligase, cytoplasmic Binder Superfamily
Class Class 4447

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
SB1518 family 7 103
Tyrosine kinase Inhibitor PKI166 Family 17 198
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Melanin-concentrating hormone receptor 1 Ligand 8-sec-butoxy-q... 30 39
Melanin-concentrating hormone receptor 1 Ligand Gnf-pf-2322 Fa... 3 95
Melanin-concentrating hormone receptor 1 Ligand ADS-102891 Family 6 51
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Metabotropic glutamate receptor 1 Ligand 4-(cyclohexyloxy)quin... 1 4
Adenosine receptor A1 and Adenosine receptor A2a ligand NSC658... 8 54
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
Cathepsin S and Cathepsin K inhibitor AGN-PC-088VBO family 3 11
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 3 6
Survival motor neuron protein inhibitor CHEMBL1307497 family 1 2
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 8
Prostaglandin D2 receptor ligand 3-[2-methoxy-6-[2-(4-methoxyp... 2 12
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Methionine--tRNA ligase inhibitor 2-[3-[(5-bromo-2-ethoxy-3-me... 9 11
Methionine--tRNA ligase inhibitor SureCN7818675 family 7 14
Methionine--tRNA ligase inhibitor 2-[3-[(3-bromo-2-ethoxy-5-me... 2 1
Methionine--tRNA ligase, cytoplasmic and Methionine--tRNA liga... 8 6
Methionine--tRNA ligase inhibitor 2-({3-[(3,5-Dichlorobenzyl)a... 5 7
Methionine--tRNA ligase inhibitor SureCN7818124 family 1 9
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 3 21
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 17
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Corticotropin-releasing factor receptor 1 ligand 3,6-diethyl-5... 7 8
Corticotropin-releasing factor receptor 1 ligand 6-ethyl-3-met... 6 10
Fatty-acid amide hydrolase 1 inhibitor (1R)-2-[[6-(3-chloro-4-... 1 4
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 8 3
Dihydrofolate reductase inhibitor 7-(3,4-dimethoxyphenyl)-6-me... 1 3
Dihydrofolate reductase inhibitor 7-(2-ethoxynaphthalen-1-yl)-... 3 2
Methionine--tRNA ligase inhibitor 2-[3-[(3,5-dibromo-2-ethoxyp... 2 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Poly [ADP-ribose] polymerase 1 inhibitor 4-[1-[3-(4-oxo-1H-qui... 1 3
Xanthine dehydrogenase/oxidase inhibitor 4-[[4-(2-aminopyrimid... 3 16
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family 2 0
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Xanthine dehydrogenase/oxidase inhibitor 5-(2-amino-4-oxo-1H-p... 8 30
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-1-N-(4... 3 9
Melanin-concentrating hormone receptor 1 ligand SureCN5431614 ... 1 2
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 10
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 0
Type-1 angiotensin II receptor ligand 2-ethyl-6-methoxy-N-[[4-... 2 0
Adenosine receptor A1 and Adenosine receptor A2a ligand 7-meth... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 3
Epidermal growth factor receptor ligand 4-Anilinoquinazoline d... 2 0
Serine/threonine-protein kinase Chk2 inhibitor (6E)-4-fluoro-6... 3 6
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 2 8


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00373042 CHEMBL161255 Bioactive 2-[3-[(2-ethoxy-3-iodo-5-methylphenyl)methylamino]propylamino]-1H-quinolin-4-one
CFAMM00373041 CHEMBL159092 Bioactive 4-ethoxy-3-methyl-5-[[3-[(4-oxo-1H-quinolin-2-yl)amino]propylamino]methyl]benzonitrile
CFAMM00373075 CHEMBL158555 Bioactive 2-[3-[(2-ethoxy-3-iodo-5-methoxyphenyl)methylamino]propylamino]-1H-quinolin-4-one
CFAMM00373074 CHEMBL345835 Bioactive 2-[3-[(2-ethoxy-5-iodo-3-prop-2-enylphenyl)methylamino]propylamino]-1H-quinolin-4-one
CFAMM00373073 CHEMBL158958 Bioactive 2-[3-[[2-ethoxy-3-methyl-5-(trifluoromethyl)phenyl]methylamino]propylamino]-1H-quinolin-4-one
CFAMM00373044 CHEMBL436610 Bioactive 2-[3-[[2-ethoxy-5-iodo-3-(methoxymethyl)phenyl]methylamino]propylamino]-1H-quinolin-4-one
CFAMM00373072 CHEMBL158758 Bioactive 2-[3-[(2-ethoxy-5-iodo-3-methylphenyl)methylamino]propylamino]-1H-quinolin-4-one
CFAMM00373078 CHEMBL157589 Bioactive 2-[3-[[2-ethoxy-3-(hydroxymethyl)-5-iodophenyl]methylamino]propylamino]-1H-quinolin-4-one
CFAMM00373043 CHEMBL161312 Bioactive 2-[3-[(2-ethoxy-3,5-diiodophenyl)methylamino]propylamino]-1H-quinolin-4-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27163 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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