CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6491
Family Name 5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic receptor ligand [(6aR,9R)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-yl]methyl cyclopentanecarboxylate;(Z)-but-2-enedioic acid family
No. of Seeds 10 No. of Other Members 9
Family Centroid CFAMM00373088 Functional Category Bioactive with Human Metabolite & Natural Product
Superfamily Alpha-1B adrenergic receptor and 5-hydroxytryptamine receptor 2A Binder Superfamily
Class Class 1218

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Histamine H1 receptor Ligand Triprolidine Family 19 316
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
5-hydroxytryptamine receptor Ligand Metergolin Family 2 11
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Proteinase-activated receptor 1 Ligand SCH-530348 Family 20 215
Toll-like receptor 9 Ligand TLR9 Agonist Family 8 8
Coagulation factor X Inhibitor Otamixaban Family 9 21
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 4
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 3 15
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
Fatty acid-binding protein, adipocyte and Fatty acid-binding p... 3 11
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Histone deacetylase Inhibitor ST-5732 Family 8 6
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 6 4
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 4 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Glucocorticoid receptor ligand SureCN5650626 family 17 25
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Prothrombin and Trypsin-1 inhibitor 1-[2-(4-benzylpiperidin-1-... 2 2
C-X-C chemokine receptor type 3 ligand (6aR,9R)-N-phenyl-4-(2-... 5 0
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 2 1
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 18
5-hydroxytryptamine receptor 5A and 5-hydroxytryptamine recept... 2 0
Gonadotropin-releasing hormone receptor ligand SureCN7997217 f... 3 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name
CFAMM00373100 CHEMBL348936 Bioactive [(6aR,10aR)-7-methyl-4-propan-2-yl-6,6a,8,10a-tetrahydroindolo[4,3-fg]quinoline-9-yl]methyl cyclopentanecarboxylate;(Z)-but-2-enedioic acid
CFAMM00373099 CHEMBL348055 Bioactive [(6aR,10aR)-7-methyl-4-propan-2-yl-6,6a,8,10a-tetrahydroindolo[4,3-fg]quinoline-9-yl]methyl cyclobutanecarboxylate;(Z)-but-2-enedioic acid
CFAMM00373089 CHEMBL347450 Bioactive [(6aR,9R)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-yl]methyl cyclobutanecarboxylate;(Z)-but-2-enedioic acid
CFAMM00373095 CHEMBL346727 Bioactive [(6aR,9R)-7-methyl-4-propan-2-yl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-yl]methyl cyclobutanecarboxylate;(Z)-but-2-enedioic acid
CFAMM00373098 CHEMBL348875 Bioactive [(6aR,9R)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-yl]methyl cyclohexanecarboxylate;(Z)-but-2-enedioic acid
CFAMM00373088 CHEMBL433689 Bioactive [(6aR,9R)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-yl]methyl cyclopentanecarboxylate;(Z)-but-2-enedioic acid
CFAMM00373097 CHEMBL160821 Bioactive [(6aR,9R)-7-methyl-4-propan-2-yl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-yl]methyl cyclopentanecarboxylate;(Z)-but-2-enedioic acid
CFAMM00373106 CHEMBL158155 Bioactive [(6aR,9R)-7-methyl-4-propan-2-yl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-yl]methyl cyclopropanecarboxylate;(Z)-but-2-enedioic acid
CFAMM00373093 CHEMBL157648 Bioactive [(6aR,9R)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-yl]methyl cycloheptanecarboxylate;(Z)-but-2-enedioic acid

Statistics of CFAM Database
 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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