CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6506
Family Name cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6409685 family
No. of Seeds 7 No. of Other Members 4
Family Centroid CFAMM00373214 Functional Category Bioactive
Superfamily cGMP-specific 3',5'-cyclic phosphodiesterase and Prelamin-A/C Binder Superfamily
Class Class 3477

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Na+-K+-ATPase transmembrane protein Inhibitor Sanguinarine Family 8 20
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Acetylcholinesterase and Cholinesterase Inhibitor 1,4-di(berbe... 5 0
Endothelin-1 receptor and Endothelin B receptor ligand (5S,6R,... 15 28
Endothelin-1 receptor and Endothelin B receptor ligand (5S,6R,... 23 8
Endothelin-1 receptor and Endothelin B receptor ligand 3-(1,3-... 1 1
Endothelin-1 receptor and Endothelin B receptor ligand SureCN1... 3 16
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 21 11
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
Leukotriene B4 receptor 1 ligand SureCN8987047 family 4 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 2 9
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Sodium-dependent serotonin transporter inhibitor (4S)-4-[4-[(2... 1 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Acetylcholinesterase and Butyrylcholinesterase inhibitor (E)-3... 4 5
Cholinesterase and Acetylcholinesterase inhibitor 6-[2-methoxy... 12 6
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR... 3 6
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 2 10
DNA topoisomerase 1 inhibitor AC1LAHQQ family 5 14
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 2 2
Indoles Metabolite 4-[N-(p-Coumaroyl)serotonin-4''-yl]-N-ferul... 3 0
NP (r)-methyl 2-(1-(3,4,5-trimethoxyphenyl)-9h-pyrido[3,4-b]in... 7 0
Putative NP ZINC12880788 Family 12 0
NP 3-(6-methoxy-3,4-dihydro-1h-pyrido[3,4-b]indol-2(9h)-yl)-1-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00373216 CHEMBL351813 Bioactive SureCN6635485
CFAMM00373222 CHEMBL158374 Bioactive 3-(1,3-benzodioxol-5-yl)-2-[(E)-3-phenylprop-2-enoyl]-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
CFAMM00373221 CHEMBL158817 Bioactive SureCN5075685
CFAMM00373214 CHEMBL157819 Bioactive SureCN6409685
CFAMM00373219 CHEMBL161408 Bioactive 3-(1,3-benzodioxol-5-yl)-N-benzyl-9-oxo-3,4-dihydro-1H-pyrrolo[3,4-b]quinoline-2-carboxamide
CFAMM00373224 CHEMBL263000 Bioactive 3-(1,3-benzodioxol-5-yl)-2-(3-phenylprop-2-ynoyl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
CFAMM00373217 CHEMBL158829 Bioactive pyridin-4-ylmethyl (3S)-3-(1,3-benzodioxol-5-yl)-9-oxo-3,4-dihydro-1H-pyrrolo[3,4-b]quinoline-2-carboxylate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26370 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543