CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6541
Family Name Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL1581094 family
No. of Seeds 1 No. of Other Members 1
Family Centroid CFAMM00373425 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor 1A and Prelamin-A/C Binder Superfamily
Class Class 216

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Ivabradine family 1 11
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Histamine H3 receptor Ligand A-349821 Family 49 228
Histamine H1 receptor Ligand MDL-105212 Family 16 56
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Caspase-3 Inhibitor 2-(4-methoxy-benzyl)isoquinoline-1,3,4-tri... 2 2
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 2
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 2 6
D(2) dopamine receptor Ligand Epidepride Family 31 66
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745OX family 2 0
Histamine H3 receptor ligand 1-(3,4-dimethoxyphenyl)-4-(4-pent... 2 0
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Leukotriene B4 receptor 1 ligand AGN-PC-00GEAR family 2 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Substance-P receptor ligand AGN-PC-075NSQ family 9 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Type-2 angiotensin II receptor ligand SureCN244657 family 7 11
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1589265 family 1 0
Pol polyprotein inhibitor CHEMBL305466 family 4 7
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Prostaglandin D2 receptor 2 and Chemoattractant receptor-homol... 1 1
Growth hormone secretagogue receptor type 1 ligand 2-[(2S)-1-[... 2 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Sodium-dependent noradrenaline transporter and Sodium-dependen... 6 6
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Cannabinoid receptor 1 ligand AGN-PC-03RV6L family 10 3
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
Sigma non-opioid intracellular receptor 1 and D(3) dopamine re... 26 8
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Cholinesterase and Acetylcholinesterase inhibitor 3,4,5-trimet... 1 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-04X9O... 2 1
Free fatty acid receptor 1 ligand (3R,4R)-3-[4-(3,4-dimethylph... 4 4
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 3 4
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
C-C chemokine receptor type 3 and Probable C-C chemokine recep... 5 2
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
D(3) dopamine receptor ligand S33084 family 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 1 5
Orexin receptor type 2 and Orexin receptor type 1 ligand 2-ben... 1 0
15-hydroxyprostaglandin dehydrogenase [NAD(+)] and Retinal deh... 1 1
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor Tetracycl... 2 0
NP ((1r,4as,8as)-4a-hydroxy-1-(3,4,5-trimethoxyphenyl)octahydr... 3 3
2-(2,4-dimethoxyphenyl)-2,3,6,7,11,12-hexahydro-[1,4]dioxepino... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00373426 CHEMBL2153073 Bioactive 2-[(E)-3-(3,4-dimethoxyphenyl)-2-(2-fluorophenyl)prop-2-enoyl]-N-hydroxy-3,4-dihydro-1H-isoquinoline-7-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24337 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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