CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6549
Family Name Coagulation factor X and Trypsin-1 inhibitor 1-(3-carbamimidoylphenyl)-N-[4-(2-sulfamoylphenyl)phenyl]imidazole-2-carboxamide;2,2,2-trifluoroacetic acid family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00290359 Functional Category Bioactive
Superfamily Glycogen synthase kinase-3 beta and Nicotinamide phosphoribosyltransferase Binder Superfamily
Class Class 853

Cousin Family NamesSeedsMembers
ATP-sensitive inward rectifier potassium channel 10 Ligand Gli... 2 45
Histamine H1 receptor Ligand Mizolastine Family 14 603
Prothrombin Inhibitor Dabigatran Family 7 182
Farnesyltransferase beta subunit, putative Inhibitor BMS214662... 11 65
BIBT986 family 7 96
SB989 family 17 91
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Protein farnesyltransferase subunit beta Inhibitor BMS-316810 ... 11 18
Farnesyltransferase beta subunit, putative and Protein farnesy... 12 4
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 8
Type-2 angiotensin II receptor and Type-1A angiotensin II rece... 10 7
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 28 9
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Coagulation factor X and Prothrombin inhibitor AGN-PC-0752MR f... 4 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Coagulation factor X inhibitor 6-chloro-N-[(3S)-1-[4-[2-[(dime... 5 8
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 3
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-075TBZ family 2 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4
Coagulation factor X and Trypsin-1 inhibitor 5-(3-carbamimidoy... 2 1
Coagulation factor X and Trypsin-1 inhibitor 3-(3-carbamimidoy... 1 0
Coagulation factor X and Trypsin-1 inhibitor 1-(3-carbamimidoy... 2 2
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
B1 bradykinin receptor ligand 2-[(2R)-7-chloro-1-naphthalen-2-... 2 0
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 15
High affinity nerve growth factor receptor ligand N-[3-amino-5... 4 10
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 1
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 10 0
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Cdc2-related kinase inhibitor N-[6-(3,5-dimethylphenyl)-1-meth... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
5-hydroxytryptamine receptor 6 ligand 8-(1-pyrrolidin-3-ylpyrr... 1 0
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-a]pyridine der... 4 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 3
B1 bradykinin receptor ligand AGN-PC-077LWO family 2 0
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 9 0
Tyrosine-protein phosphatase non-receptor type 1 ligand sodium... 2 6
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-075O... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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