CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM657
Family Name Histamine H3 receptor and Potassium voltage-gated channel subfamily H member 2 ligand SureCN1641496 family
No. of Seeds 6 No. of Other Members 14
Family Centroid CFAMM00256643 Functional Category Bioactive with Natural Product
Superfamily Acetylcholinesterase and Histamine H3 receptor Binder Superfamily
Class Class 3184

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Platelet-derived growth factor receptor alpha and Platelet-der... 5 48
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 16
Metabotropic glutamate receptor 5 Ligand 2-methyl-4-(pyridin-3... 10 35
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
Indoleamine 2,3-dioxygenase 1 Inhibitor N-[2-(indol-3-yl)ethyl... 2 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
Histamine H3 receptor Ligand ST-1025 Family 2 22
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Arachidonate 15-lipoxygenase Inhibitor PD-146176 Family 1 3
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 20
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 3
Histamine H1 receptor and Cytochrome P450 2D6 ligand 2-[3-[(1R... 1 10
5-hydroxytryptamine receptor 6 ligand CHEMBL1950756 family 8 8
Progesterone receptor and Androgen receptor ligand 5-[4-[(Z)-C... 2 5
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 3
Nuclear receptor ROR-gamma and Niemann-Pick C1 protein ligand ... 1 12
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 4
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 3 7
Histamine H1 receptor and Cytochrome P450 2D6 ligand N-methyl-... 1 0
Sigma non-opioid intracellular receptor 1 ligand SureCN7434677... 1 0
Melanin-concentrating hormone receptor 2 ligand N,N-dimethyl-3... 2 2
Amyloid beta A4 protein and Luciferin 4-monooxygenase inhibito... 11 46
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 0
5-hydroxytryptamine receptor 6 ligand 2-methyl-5-methylsulfany... 1 1
Metabotropic glutamate receptor 5 ligand 3-methyl-1-(2-thiophe... 2 1
5-hydroxytryptamine receptor 1A and Alpha-2C adrenergic recept... 2 2
Epidermal growth factor receptor and Vascular endothelial grow... 14 19
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 3 4
Amyloid beta A4 protein inhibitor SureCN2465837 family 4 2
Protein kinase C theta type and Protein kinase C delta type in... 4 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Muscleblind-like protein 1 and Huntingtin inhibitor AC1LYOWT f... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00314068 CHEMBL1822868 Bioactive AGN-PC-0BFR1Z
CFAMM00314082 CHEMBL1085591 Bioactive SureCN1639579
CFAMM00314078 CHEMBL1822869 Bioactive 6-[2-(2-methylpyrrolidin-1-yl)ethyl]-2-thiophen-2-ylquinoline
CFAMM00314077 CHEMBL1085572 Bioactive SureCN1639901

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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