CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6574
Family Name Survival motor neuron protein inhibitor CHEMBL1583999 family
No. of Seeds 1 No. of Other Members 3
Family Centroid CFAMM00373582 Functional Category Bioactive
Superfamily Insulin-like growth factor 1 receptor and Insulin receptor Binder Superfamily
Class Class 195

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Type-1 angiotensin II receptor Ligand Tasosartan Family 10 29
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... 28 56
HER Inhibitor AC480 Family 4 67
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
PF-4217903 family 14 65
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 9
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Histamine H4 receptor Ligand A-943931 Family 14 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 5 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN5... 6 24
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07RDWA fa... 1 4
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... 9 11
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3
3-phosphoinositide-dependent protein kinase 1 and Rho-associat... 12 11
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 4
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Casein kinase II subunit alpha inhibitor AGN-PC-0766PM family 4 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[(3S)-3-[(4... 2 1
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 3 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Casein kinase II subunit alpha and Homeodomain-interacting pro... 5 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 4 2
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 3 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor 2,... 4 4
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 6
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 3 0
Mast/stem cell growth factor receptor Kit and Proto-oncogene t... 3 5
Proto-oncogene tyrosine-protein kinase Src and Mast/stem cell ... 4 1
Tyrosine-protein kinase JAK2 inhibitor N-(3-methylphenyl)-5-(3... 2 4
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 4 0
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Dipeptidyl peptidase 4 inhibitor 2-(3-aminopiperidin-1-yl)-3-b... 4 1
Casein kinase II subunit alpha inhibitor CHEMBL401945 family 12 1
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Corticotropin-releasing factor receptor 1 ligand SureCN7215846... 4 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 6 6
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 7
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 4
Alpha-1B adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 1
Corticotropin-releasing factor receptor 1 ligand 4-[7-(dipropy... 1 1
High affinity nerve growth factor receptor ligand SureCN490352... 3 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 11 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Corticotropin-releasing factor receptor 1 ligand 3-[6-(dimethy... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27526 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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