CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6585
Family Name Neuronal acetylcholine receptor subunit alpha-4 and Neuronal acetylcholine receptor subunit beta-2 ligand SureCN6586885 family
No. of Seeds 2 No. of Other Members 4
Family Centroid CFAMM00373640 Functional Category Bioactive
Superfamily Nicotinic acetylcholine receptor Ligand AZD0328 Superfamily
Class Class 1002

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Acetylcholinesterase Inhibitor Pyridostigmine Family 5 197
Histamine H1 receptor Ligand Doxylamine Family 2 91
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... 49 172
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
PF-02545920 family 16 140
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Neuronal acetylcholine receptor subunit beta-2 Ligand ABT-594 ... 4 5
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Translocator protein inhibitor SureCN13502542 family 20 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Neuronal acetylcholine receptor subunit alpha-3 and Neuronal a... 2 0
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 6 4
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 7
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
Thromboxane A2 receptor and Thromboxane-A synthase ligand Ici ... 3 17
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Serine/threonine-protein kinase B-raf inhibitor pyrrole-based ... 2 0
RAC-alpha serine/threonine-protein kinase inhibitor N-[(2S)-1-... 2 1
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Sodium-dependent serotonin transporter and Sodium-dependent do... 2 0
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 6 1
Translocator protein inhibitor N-methyl-2-(2-oxo-5-pyridin-4-y... 8 15
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 2
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Neuronal acetylcholine receptor subunit alpha-7 ligand 5-[6-[[... 1 0
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 3
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Renin inhibitor SureCN6042213 family 2 3
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 0
Protein kinase C theta type and Protein kinase C delta type in... 10 7
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 2
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
Neuronal acetylcholine receptor subunit alpha-3 and Neuronal a... 4 1
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 6 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 1
Glutamate receptor ionotropic, NMDA 2B and Cytochrome P450 2D6... 2 3
Lysophosphatidic acid receptor 1 and Lysophosphatidic acid rec... 3 6
Reverse transcriptase/RNaseH inhibitor 6Et-7,9-diMe-PBOA-5thio... 1 1
P2X purinoceptor 7 inhibitor 3-[1-[4-(3-nitrophenyl)phenoxy]-4... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00373640 CHEMBL158529 Bioactive SureCN6586885
CFAMM00373639 CHEMBL158834 Bioactive SureCN6583213

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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