CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6593
Family Name Cruzipain and Cathepsin L1 inhibitor pyridin-3-ylmethyl N-[(2S)-1-[[(3S)-1-tert-butylsulfanyl-2-oxo-5-phenylpentan-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate family
No. of Seeds 7 No. of Other Members 4
Family Centroid CFAMM00325360 Functional Category Bioactive
Superfamily Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Cyclo(-l-am7(s2py)-aib-l-ser(bzl)-d-pro-) Superfamily
Class Class 3038

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Ritonavir Family 12 49
HIV-1 protease Inhibitor Atazanavir Family 16 58
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Cycl... 1 1
Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8
Neutrophil elastase inhibitor SureCN7284457 family 4 6
Cathepsin L1 and Cathepsin K inhibitor benzyl N-[(2S)-1-oxo-3-... 1 1
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 8 8
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
Histone deacetylase 2 and Histone deacetylase 1 inhibitor benz... 1 10
Histone deacetylase 2 and Histone deacetylase 1 inhibitor 9H-f... 1 7
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16b ... 2 0
Pol polyprotein inhibitor AC1LAHRX family 4 0
Beta-secretase 1 and Cathepsin B inhibitor SureCN14347937 family 4 1
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7013744... 2 3
Pol polyprotein inhibitor [(2R,3R)-1,1-dioxo-2-propan-2-ylthio... 11 0
Beta-secretase 1 and Cathepsin B inhibitor SureCN14347784 family 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00373710 CHEMBL351045 Bioactive pyridin-3-ylmethyl N-[(2S)-1-[[(2S)-4-tert-butylsulfanyl-3-oxo-1-phenylbutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate
CFAMM00373709 CHEMBL158567 Bioactive pyridin-3-ylmethyl N-[(2S)-1-oxo-1-[[(2S)-3-oxo-1-phenyl-4-(3-phenylpropylsulfanyl)butan-2-yl]amino]-3-phenylpropan-2-yl]carbamate
CFAMM00373707 CHEMBL158806 Bioactive pyridin-3-ylmethyl N-[(2S)-1-[[(2S)-4-tert-butylsulfanyl-3-oxo-1-phenylbutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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