CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6608
Family Name Prelamin-A/C and Survival motor neuron protein inhibitor CHEMBL1586758 family
No. of Seeds 1 No. of Other Members 7
Family Centroid CFAMM00373831 Functional Category Bioactive
Superfamily Survival motor neuron protein and Prelamin-A/C Binder Superfamily 2
Class Class 3617

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Integrin alpha-4 Inhibitor R1295 Family 18 59
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
Neuropeptide Y receptor type 1 Ligand BMS-193885 Family 3 11
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Alpha-1 adrenergic receptor Ligand DC-015 Family 8 25
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 7 23
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Extracellular calcium-sensing receptor Ligand 2-furan-2-yl-3-p... 4 119
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Neuropeptide Y receptor type 1 Ligand N-arylpiperazine Derivat... 5 4
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
Disintegrin and metalloproteinase domain-containing protein 17... 3 0
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
D(3) dopamine receptor and D(1A) dopamine receptor ligand N-[(... 6 14
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 7 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
Vasopressin V1b receptor ligand AGN-PC-09QGT9 family 4 123
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Integrin beta-1 and Integrin alpha-4 inhibitor AGN-PC-02YIN5 f... 3 5
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 0
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 23 10
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 2 1
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
C-X-C chemokine receptor type 3 ligand N-(2-ethoxyethyl)-N-[(1... 1 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 8
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 10
Ghrelin/growth hormone secretagogue receptor and Cytochrome P4... 5 20
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 7
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 11 4
Histamine H3 receptor and Potassium voltage-gated channel subf... 16 2
Histamine H3 receptor ligand AGN-PC-00AE5Q family 13 13
Histamine H3 receptor and Potassium voltage-gated channel subf... 28 30
Histamine H3 receptor ligand AGN-PC-03Z8HJ family 4 1
Trypsin-1 inhibitor N-[7-amino-1-[2-(4-carbamoylphenyl)ethylam... 1 0
5-hydroxytryptamine receptor 7 ligand 4-[4-(2-ethoxyphenyl)pip... 2 5
DNA polymerase III PolC-type inhibitor 6-(3-ethyl-4-methylanil... 1 0
Calcitonin gene-related peptide type 1 receptor ligand 2-(4-me... 4 4
Gonadotropin-releasing hormone receptor ligand CHEMBL260816 fa... 1 0
Beta-lactamase and 4'-phosphopantetheinyl transferase ffp inhi... 1 0
NP (s)-3-(2,5-dioxo-2,3,4,5-tetrahydro-1h-benzo[e][1,4]diazepi... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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