CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6618
Family Name Inositol monophosphatase 1 inhibitor CHEMBL1588383 family
No. of Seeds 1 No. of Other Members 6
Family Centroid CFAMM00373883 Functional Category Bioactive
Superfamily Survival motor neuron protein and Nonstructural protein 1 Binder Superfamily
Class Class 834

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
AP26113 family 16 90
SB1518 family 7 103
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
E7050 family 2 13
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Hepatocyte growth factor receptor Ligand BMS-777607 Family 10 1
Mitogen-activated protein kinase 14 Inhibitor Pamapimod Family 15 7
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
5-hydroxytryptamine receptor 1A Ligand CP-293019 Family 9 24
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Vascular endothelial growth factor receptor 2 ligand 1-[4-[6-a... 11 13
Glycogen synthase kinase-3 beta inhibitor 6-[(2S)-2-(2-methoxy... 1 0
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 2 0
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 3 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 5 1
Vascular endothelial growth factor receptor 2 ligand urea deri... 2 1
Cathepsin K and Cathepsin L1 inhibitor CHEBI:43424 family 2 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-009TSL... 3 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Receptor tyrosine-protein kinase erbB-2 ligand N-[3-chloro-4-(... 4 3
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Wee1-like protein kinase and ALK tyrosine kinase receptor liga... 1 9
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
Tyrosine-protein kinase Lck inhibitor SureCN374434 family 1 1
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 1 3
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 1 2
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
Acyl-CoA desaturase inhibitor SureCN1182546 family 2 5
Vascular endothelial growth factor receptor 2 ligand SureCN472... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00373881 CHEMBL2437471 Bioactive N-[3-[2-(4-methoxyanilino)-6-methyl-7-oxopteridin-8-yl]phenyl]prop-2-enamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26839 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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