CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6654
Family Name Histamine H3 receptor ligand SureCN2784306 family
No. of Seeds 5 No. of Other Members 3
Family Centroid CFAMM00374076 Functional Category Bioactive with Natural Product
Superfamily Reverse transcriptase/RNaseH and Prelamin-A/C Binder Superfamily
Class Class 2593

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
Cathepsin K Inhibitor Relacatib Family 26 32
Phospholipase A2, membrane associated Inhibitor Varespladib Fa... 37 190
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor GSK2... 15 18
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Neuronal acetylcholine receptor subunit alpha-4 Ligand TC-5619... 3 61
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Fatty-acid amide hydrolase 1 Inhibitor 1-(5-(pyridin-2-yl)oxaz... 10 142
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Peroxisome proliferator-activated receptor delta ligand SureCN... 8 19
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Pol polyprotein inhibitor AC1LARNY family 28 17
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... 2 7
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 3
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Retinoic acid receptor beta and Retinoic acid receptor alpha l... 2 2
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 7
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 4 0
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Fatty-acid amide hydrolase 1 inhibitor methyl 6-[2-[3-(4-pheny... 8 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 11 11
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Renin inhibitor [2-(3-fluoro-2,6-dimethylphenoxy)-1-phenylpyrr... 5 12
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[(1... 2 0
Sphingosine 1-phosphate receptor 1 ligand 6-[2-[4-phenyl-3-(tr... 2 3
Cytosolic phospholipase A2 inhibitor AGN-PC-00BH8R family 6 13
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 3 2
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 10 5
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
C-C chemokine receptor type 5 ligand N-methyl-4-[6-methyl-5-[[... 2 2
Macrophage colony-stimulating factor 1 receptor ligand 5-cyano... 1 0
Cathepsin K and Cathepsin L1 inhibitor AC1NR9VX family 2 2
Platelet-activating factor receptor ligand N,N-dimethyl-6-phen... 12 18
Cannabinoid receptor 1 ligand (4-hydroxynaphthalen-1-yl)-[1-(2... 2 0
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 1
RAC-alpha serine/threonine-protein kinase inhibitor Isoquinoli... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
CGMP-dependent protein kinase inhibitor AGN-PC-075IHL family 2 8
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
Collagenase 3 inhibitor SureCN1316041 family 4 3
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Metabotropic glutamate receptor 5 ligand 3-fluoro-5-(5-pyridin... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00374076 CHEMBL159087 Bioactive SureCN2784306
CFAMM00374075 CHEMBL423180 Bioactive 3-(2,3-dihydro-1-benzofuran-5-yl)-2-(5-pyridin-3-ylfuran-2-carbonyl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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