CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6657
Family Name Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[4-(4-methylpiperazin-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine family
No. of Seeds 2 No. of Other Members 11
Family Centroid CFAMM00374084 Functional Category Bioactive
Superfamily Corticotropin-releasing factor receptor 1 Ligand BMS-561388 Superfamily
Class Class 2074

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Corticotropin-releasing factor receptor 1 Ligand GSK561679 Family 5 6
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
SB1518 family 7 103
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Ibrutinib family 2 27
PF-02545920 family 16 140
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Serine/threonine-protein kinase Chk2 Inhibitor 5-nitro-2-(4-ph... 6 3
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 4 32
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Melanin-concentrating hormone receptor 1 Ligand Gnf-pf-2322 Fa... 3 95
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 37
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Corticotropin-releasing factor receptor 1 Ligand BMS-561388 Fa... 10 16
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-072YMN ... 7 11
Serine/threonine-protein kinase B-raf inhibitor SureCN1013580 ... 2 0
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-072YXQ ... 2 1
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Epidermal growth factor receptor and Tyrosine-protein kinase A... 4 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 9 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CC4... 20 7
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Cathepsin S and Cathepsin K inhibitor AGN-PC-088VBO family 3 11
Epidermal growth factor receptor and Cyclin-dependent kinase 1... 3 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 31 11
Proto-oncogene tyrosine-protein kinase Src and Phosphatidylino... 4 20
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 3 6
Tyrosine-protein kinase ABL1 and Tyrosine-protein kinase HCK i... 2 2
Tyrosine-protein kinase HCK and Proto-oncogene tyrosine-protei... 5 9
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 12 8
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Translocator protein inhibitor AGN-PC-080ILF family 9 3
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 5
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 4
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 5
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 7 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... 3 4
Mitogen-activated protein kinase 10 and Transcription factor A... 1 1
Neuropeptide Y receptor type 1 ligand CP-671906 family 10 0
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Voltage-dependent calcium channel subunit alpha-2/delta-1 and ... 9 15
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Corticotropin-releasing factor receptor 1 ligand 6-ethyl-3-met... 6 10
Corticotropin-releasing factor receptor 1 ligand CHEMBL1819076... 2 0
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 0
Corticotropin-releasing factor receptor 1 ligand 5-N-(2-chloro... 7 1
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 6
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 3
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 7 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Tyrosine-protein kinase JAK2 inhibitor N-[3-chloro-4-(4-methyl... 2 1
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 17
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 5 8
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 4 4
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... 4 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YLX fa... 3 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN6387344 f... 6 11
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 9
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 7 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
Fibroblast growth factor receptor 1 and Vascular endothelial g... 3 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 4 0
Vascular endothelial growth factor receptor 1 and Fibroblast g... 3 7
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 1-... 8 6
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-[2-... 5 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Estrogen receptor and Estrogen receptor beta ligand 4-[3-[4-(2... 1 0
Metabotropic glutamate receptor 2 ligand 8-chloro-3-(cycloprop... 6 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Mitogen-activated protein kinase 1 inhibitor 1-[(3R)-1-[(2-flu... 1 0
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Hepatocyte growth factor receptor ligand 6-[(1S)-1-[6-(2,3-dih... 1 5
Substance-P receptor ligand (2S,3S)-N-[[2-methoxy-5-(tetrazol-... 2 0
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Melanin-concentrating hormone receptor 1 ligand SureCN5431614 ... 1 2
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 7 6
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 7 1
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 10
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Type-1 angiotensin II receptor ligand 2-ethyl-6-methoxy-N-[[4-... 2 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 4 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 0
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 4
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Adenosine receptor A2a ligand AGN-PC-077RYF family 3 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CCL... 3 0
Protein kinase C zeta type and Cyclin-dependent kinase 2 inhib... 2 4
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Nociceptin receptor and Delta-type opioid receptor ligand 2-[3... 2 1
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CCI... 3 0
Oxytocin receptor ligand AGN-PC-07C71T family 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Aurora kinase A and Glycogen synthase kinase-3 beta inhibitor ... 1 2
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-07CQG5 ... 2 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
Glucokinase inhibitor AGN-PC-03ZE5E family 1 0
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor AGN-PC... 2 0
Acyl-CoA desaturase 1 inhibitor Pyridazine, 3-[4-(2-ethylpheno... 4 2
Delta-type opioid receptor and 5-hydroxytryptamine receptor 7 ... 1 6
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Lysosomal Pro-X carboxypeptidase inhibitor 4-[6-[(2S)-2-(5,6-d... 2 2
Dihydrofolate reductase inhibitor 5-[3-(3-methoxy-5-morpholin-... 2 0
Receptor tyrosine-protein kinase erbB-2 and Insulin-like growt... 4 2
Serine/threonine-protein kinase PLK1 inhibitor SureCN3992071 f... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00374084 CHEMBL2414546 Bioactive 5-(3-methoxyphenyl)-N-[4-(4-methylpiperazin-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine
CFAMM00374083 CHEMBL2414544 Bioactive 5-(4-methoxyphenyl)-N-[4-(4-methylpiperazin-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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