CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6666
Family Name Methionine--tRNA ligase, cytoplasmic and Methionine--tRNA ligase inhibitor 2-[3-[(6,8-dibromo-1,2,3,4-tetrahydroquinolin-4-yl)amino]propylamino]-1H-quinolin-4-one family
No. of Seeds 8 No. of Other Members 6
Family Centroid CFAMM00374125 Functional Category Bioactive
Superfamily Methionine--tRNA ligase and Methionine--tRNA ligase, cytoplasmic Binder Superfamily
Class Class 4447

Cousin Family NamesSeedsMembers
Tyrosine kinase Inhibitor PKI166 Family 17 198
Adenosine receptor A1 and Adenosine receptor A2a ligand NSC658... 8 54
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7
Adenosine receptor A1 and Adenosine receptor A2a ligand (6E)-6... 2 2
Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... 9 32
Methionine--tRNA ligase inhibitor 2-[3-[(5-bromo-2-ethoxy-3-me... 9 11
Methionine--tRNA ligase inhibitor 2-[3-[(3-bromo-2-ethoxy-5-me... 2 1
Methionine--tRNA ligase inhibitor 2-({3-[(3,5-Dichlorobenzyl)a... 5 7
Methionine--tRNA ligase inhibitor SureCN7818124 family 1 9
Methionine--tRNA ligase inhibitor SureCN8172942 family 3 1
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Methionine--tRNA ligase inhibitor 2-[3-[(6-ethyl-8-iodo-1,2,3,... 1 0
Methionine--tRNA ligase inhibitor 2-[3-[(3,5-dibromo-2-ethoxyp... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor 4-[1-[3-(4-oxo-1H-qui... 1 3
Serine/threonine-protein kinase Chk1 inhibitor SureCN6387344 f... 6 11
Lysine--tRNA ligase inhibitor 4-[[[2-(2-piperazin-1-ylpyridin-... 2 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 10
Thymidylate synthase inhibitor 3-(methylamino)-5,6-dihydro-4H-... 2 19
Adenosine receptor A1 and Adenosine receptor A2a ligand 7-meth... 2 0
Serine/threonine-protein kinase Chk2 inhibitor (6E)-4-fluoro-6... 3 6
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 2 8


External ID

Functional Category

Molecule Name

CFAMM00374131 CHEMBL162356 Bioactive SureCN8188897
CFAMM00374130 CHEMBL160191 Bioactive SureCN7818367
CFAMM00374120 CHEMBL159197 Bioactive SureCN7821287
CFAMM00374129 CHEMBL425169 Bioactive SureCN178850
CFAMM00374126 CHEMBL161864 Bioactive SureCN5668282
CFAMM00374125 CHEMBL304237 Bioactive 2-[3-[(6,8-dibromo-1,2,3,4-tetrahydroquinolin-4-yl)amino]propylamino]-1H-quinolin-4-one
CFAMM00374124 CHEMBL161213 Bioactive 2-[3-[(8-bromo-6-methyl-1,2,3,4-tetrahydroquinolin-4-yl)amino]propylamino]-1H-quinolin-4-one
CFAMM00374123 CHEMBL161212 Bioactive 2-[3-[(6-bromo-8-methyl-1,2,3,4-tetrahydroquinolin-4-yl)amino]propylamino]-1H-quinolin-4-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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