CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6681
Family Name Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha and Protein farnesyltransferase subunit beta inhibitor (2S)-2-[[4-[(E)-2-(4-methoxypyridin-3-yl)ethenyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00374283 Functional Category Bioactive
Superfamily Protein farnesyltransferase subunit beta and Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Binder Superfamily
Class Class 137

Cousin Family NamesSeedsMembers
Farnesyltransferase beta subunit, putative Inhibitor AZD3409 F... 2 2
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Renin Inhibitor CP-305202 Family 9 30
Endothelin B receptor Ligand IRL-2500 Family 34 87
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 17 14
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 13 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 8
B2 bradykinin receptor ligand SureCN7012818 family 1 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 1
Thromboxane-A synthase and Thromboxane A2 receptor ligand Sure... 5 37
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 3
Peroxisome proliferator-activated receptor gamma and Peroxisom... 3 0
Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(meth... 1 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 15
Leukotriene A-4 hydrolase inhibitor SureCN3030546 family 9 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00374282 CHEMBL163102 Bioactive (2S)-2-[[2-(2-methylphenyl)-4-[(E)-2-(4-oxo-1H-pyridin-3-yl)ethenyl]benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00374281 CHEMBL164537 Bioactive (2S)-2-[[2-(2-methylphenyl)-4-[(E)-2-(4-propoxypyridin-3-yl)ethenyl]benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00374283 CHEMBL159326 Bioactive (2S)-2-[[4-[(E)-2-(4-methoxypyridin-3-yl)ethenyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26843 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543