CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6685
Family Name Melanocortin receptor 4 ligand AGN-PC-076AML family
No. of Seeds 3 No. of Other Members 24
Family Centroid CFAMM00374347 Functional Category Bioactive
Superfamily Type-1 angiotensin II receptor and Coagulation factor X Binder Superfamily
Class Class 1256

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Histamine H1 receptor Ligand Astemizole Family 7 240
Prothrombin Inhibitor Dabigatran Family 7 182
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
BIBT986 family 7 96
SB989 family 17 91
Eluxadoline family 4 85
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 4 32
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 4 4
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Acetylcholinesterase inhibitor SureCN251059 family 2 16
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Thromboxane A2 receptor ligand AC1NSKJR family 13 42
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Mitogen-activated protein kinase 14 inhibitor DEL-B, 14b family 2 0
Adenosine receptor A2a ligand AGN-PC-01LVXW family 2 25
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
DNA-(apurinic or apyrimidinic site) lyase and Nuclear receptor... 2 10
Thyroid hormone receptor beta ligand CHEMBL1325165 family 1 6
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 2
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 1
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Prothrombin inhibitor AGN-PC-09QJ1N family 2 1
Serine/threonine-protein kinase Chk2 inhibitor SureCN3919556 f... 4 8
Melanin-concentrating hormone receptor 1 ligand SureCN3334861 ... 1 3
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Elongation factor 1-alpha 1 and Elongation factor 1-alpha 2 in... 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 7
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Histamine H3 receptor ligand SureCN2878688 family 8 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 1... 1 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 4 29
Smoothened homolog inhibitor N-[3-(1H-benzimidazol-2-yl)phenyl... 2 1
Type-1 angiotensin II receptor ligand N-[2-(3-methoxyphenyl)et... 2 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Coagulation factor X inhibitor AGN-PC-07C10A family 3 2
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
ALK tyrosine kinase receptor ligand 4-fluoro-N-[1-[4-(propan-2... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 2 1
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Melanocortin receptor 4 ligand AGN-PC-076AMT family 2 9
Bifunctional epoxide hydrolase 2 inhibitor 8-(1H-benzimidazole... 1 0
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Gonadotropin-releasing hormone receptor ligand AGN-PC-074DFG f... 2 1
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
5-hydroxytryptamine receptor 6 ligand 2-[(2Z)-2-[3-[(3-methoxy... 1 11
Histamine H3 receptor ligand AGN-PC-075YVW family 1 2
Tyrosine-protein kinase Lck inhibitor SureCN374434 family 1 1
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Gastrin/cholecystokinin type B receptor ligand AGN-PC-077L8M f... 24 10
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RDJ family 15 1
5-hydroxytryptamine receptor 2B ligand SureCN1299002 family 2 8
Cholecystokinin receptor type A ligand SureCN3132309 family 11 0
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Nociceptin receptor and Delta-type opioid receptor ligand 2-[3... 2 1
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RCV family 2 1
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07C5JC family 1 3
Delta-type opioid receptor and Kappa-type opioid receptor liga... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0
Neuropeptide Y receptor type 5 ligand SureCN8149543 family 1 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 1
Tryptase alpha/beta-1 and Tryptase delta inhibitor AGN-PC-0763... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00374340 CHEMBL232161 Bioactive SureCN13124828
CFAMM00374339 CHEMBL1825123 Bioactive SureCN4542884
CFAMM00374347 CHEMBL429943 Bioactive AGN-PC-076AML

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27038 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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