CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6686
Family Name Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha and Protein farnesyltransferase subunit beta inhibitor (2S)-2-[[4-[(E)-2-[4-[hydroxy(phenyl)methyl]pyridin-3-yl]ethenyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid family
No. of Seeds 6 No. of Other Members 4
Family Centroid CFAMM00374358 Functional Category Bioactive
Superfamily Caspase-1 and Cytochrome P450 3A4 Binder Superfamily
Class Class 137

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Indinavir Family 36 211
HIV protease Inhibitor Saquinavir Family 64 428
HIV-1 protease Inhibitor Atazanavir Family 16 58
Coagulation factor X Inhibitor Otamixaban Family 9 21
CP-18770 family 6 27
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Renin Inhibitor CP-305202 Family 9 30
Endothelin B receptor Ligand IRL-2500 Family 34 87
Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-5-[[(2S)-2-[... 3 0
Pol polyprotein inhibitor AC1LAD48 family 19 5
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 17 14
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Plasmepsin-1 and Plasmepsin-2 inhibitor Statine-like inhibitor... 13 5
Pol polyprotein inhibitor N-[3-[[(4R,5R,6R)-4-benzyl-5-hydroxy... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 13 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 8
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 0
C-C chemokine receptor type 1 ligand N-[(2S,3S,5R)-5-carbamoyl... 10 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 3
Pol polyprotein inhibitor 2-[(2R,3S)-3-[[(2R)-2-acetamido-3-qu... 5 3
Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 1 0
Pol polyprotein inhibitor AC1LAHQ9 family 8 15
Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(meth... 1 1
Rho-associated protein kinase 2 inhibitor 2-hydroxyethyl 3-[2-... 2 0
Pol polyprotein inhibitor N-tert-butyl-2-[(2R,3S)-2-hydroxy-3-... 1 0
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 4 2
Beta-3 adrenergic receptor ligand SureCN5704018 family 4 1
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 2 1
Thromboxane-A synthase inhibitor SureCN9825871 family 6 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00374362 CHEMBL262187 Bioactive (2S)-2-[[2-(2-methylphenyl)-4-[(Z)-3-[(2-methylpropan-2-yl)oxy]-3-oxo-1-pyridin-3-ylprop-1-en-2-yl]benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00374361 CHEMBL162868 Bioactive (2S)-2-[[4-[(E)-2-[4-[hydroxy(diphenyl)methyl]pyridin-3-yl]ethenyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00374354 CHEMBL163559 Bioactive (2S)-2-[[4-[(E)-2-[4-(1-hydroxycyclohexyl)pyridin-3-yl]ethenyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00374358 CHEMBL159390 Bioactive (2S)-2-[[4-[(E)-2-[4-[hydroxy(phenyl)methyl]pyridin-3-yl]ethenyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00374363 CHEMBL352208 Bioactive (2S)-2-[[4-[(E)-2-[4-[cyclohexyl(hydroxy)methyl]pyridin-3-yl]ethenyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00374356 CHEMBL347874 Bioactive (2S)-2-[[4-[(E)-2-[4-[1-adamantyl(hydroxy)methyl]pyridin-3-yl]ethenyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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